Effect of sumac extract on serum oxidative status, RANKL/OPG system and alveolar bone loss in experimental periodontitis in rats

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dc.contributor.authorSaglam, Mehmet
dc.contributor.authorKoseoglu, Serhat
dc.contributor.authorHatipoglu, Mukerrem
dc.contributor.authorEsen, Haci Hasan
dc.contributor.authorKoksal, Ekrem
dc.date.accessioned2024-02-23T14:32:11Z
dc.date.available2024-02-23T14:32:11Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractObjectives: Sumac (Rhus coriaria L.) is widely used spice which has several properties such as antioxidant, anti-inflammatory and antimicrobial. The purpose of this animal study was to evaluate the effects of sumac extract on levels of receptor activator of nuclear factor-kappa B ligand (RANKL), osteoprotegerin (OPG) expression, serum oxidative status, and alveolar bone loss in experimental periodontitis. Material and Methods: Twenty-four Wistar rats were separated into three groups: non-ligated (NL, n=8), ligature only (LO, n=8), and ligature and treated with sumac extract (S, n=8) (20 mg/kg per day for 11 days). A 4/0 silk suture was placed around the mandibular right first molars subgingivally; after 11 days, the rats were sacrificed, and alveolar bone loss was histometrically measured. The detection of RANKL and OPG were immunohistochemically performed. Levels of serum total antioxidant status (TAS)/total oxidant status (TOS), and oxidative stress index (OSI) were also analyzed. Results: Alveolar bone loss was significantly greater in the LO group compared to the S and NL groups (p<0.05). The number of inflammatory cell infiltrate (ICI) and osteoclasts in the LO group was significantly higher than that of the NL and S groups (p<0.05). The number of osteoblasts in the LO and S groups was significantly higher than that of the NL group (p<0.05). There were significantly more RANKL-positive cells in the LO group than in the S and NL groups (p<0.05). OPG-positive cells were higher in S group than in LO and NL groups (p<0.05). TOS and OSI levels were significantly reduced in S group compared to LO group (P<0.05) and TAS levels were similar in S and NL group (p>0.05). Conclusions: The present study showed that systemic administration of sumac extract may reduce alveolar bone loss by affecting RANKL/OPG balance, TOS and OSI levels in periodontal disease in rats.en_US
dc.identifier.doi10.1590/1678-775720140288
dc.identifier.endpage41en_US
dc.identifier.issn1678-7757
dc.identifier.issn1678-7765
dc.identifier.issue1en_US
dc.identifier.pmid25760266en_US
dc.identifier.scopus2-s2.0-84924455974en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage33en_US
dc.identifier.urihttps://doi.org/10.1590/1678-775720140288
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15531
dc.identifier.volume23en_US
dc.identifier.wosWOS:000351541300007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherUniv Sao Paulo Fac Odontologia Bauruen_US
dc.relation.ispartofJournal Of Applied Oral Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRhusen_US
dc.subjectAlveolar Bone Lossen_US
dc.subjectPeriodontal Diseasesen_US
dc.subjectReceptor Activator Of Nuclear Factor-Kappa B Liganden_US
dc.subjectOsteoprotegerinen_US
dc.titleEffect of sumac extract on serum oxidative status, RANKL/OPG system and alveolar bone loss in experimental periodontitis in ratsen_US
dc.typeArticleen_US

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