The relationship between inflammation markers and ketonuria in hyperemesis gravidarum

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dc.contributor.authorSoysal, Cenk
dc.contributor.authorIsikalan, Mehmet Murat
dc.contributor.authorBiyik, Ismail
dc.contributor.authorErten, Ozlem
dc.contributor.authorInce, Onur
dc.date.accessioned2024-02-23T14:24:31Z
dc.date.available2024-02-23T14:24:31Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractObjective Hyperemesis gravidarum is an illness that starts in early pregnancy and manifests itself with oral intake problems, electrolyte imbalance, ketonuria, and weight loss. Inflammation is closely associated with the hyperemesis gravidarum, and inflammatory indicators have been studied to understand its pathophysiology. This study investigates the relationship of ketonuria levels with inflammatory markers platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and neutrophil-to-lymphocyte ratio (NLR) for hyperemesis gravidarum patients. Material and Methods This retrospective case control study was conducted at Kutahya Medical Sciences University Tertiary Research and Training Hospital between December 2019 and December 2020. A total of 173 pregnancies, 82 of them with hyperemesis gravidarum and 91 of them low-risk pregnancies were included in the study. The patients' demographic profiles and laboratory parameters were recorded. The patients were divided into hyperemesis gravidarum and control groups and the groups were compared for the levels of inflammation markers. For the hyperemesis gravidarum group, the relationship between ketonuria levels and the inflammation severity was investigated. Results MLR, NLR, PLR levels were higher in the hyperemesis gravidarum group than the control group in a statistically significant way (p < 0.001 for all of the comparisons). The hyperemesis gravidarum group was subdivided into four groups based on their ketonuria levels, and their MLR, NLR, PLR levels were compared. The differences between the groups were statistically significant (p < 0.001) and the indicators increased with the ketonuria levels. Finally, ketonuria levels had a positive and significant correlation with MLR (rho =0.67, p < 0.001), PLR (rho =0.67, p < 0.001), and NLR (rho =0.8, p < 0.001). Conclusion Hyperemesis gravidarum patients have higher levels of hematologic inflammation indicators than healthy pregnant patients. For these patients, the levels of the indicators increase with ketonuria levels.en_US
dc.identifier.doi10.1111/jog.14857
dc.identifier.endpage3083en_US
dc.identifier.issn1341-8076
dc.identifier.issn1447-0756
dc.identifier.issue9en_US
dc.identifier.pmid34107554en_US
dc.identifier.scopus2-s2.0-85107608617en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage3078en_US
dc.identifier.urihttps://doi.org/10.1111/jog.14857
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13981
dc.identifier.volume47en_US
dc.identifier.wosWOS:000659252600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Obstetrics And Gynaecology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHyperemesis Gravidarumen_US
dc.subjectInflammationen_US
dc.subjectKetonuriaen_US
dc.subjectMonocyte-To-Lymphocyte Ratioen_US
dc.subjectNeutrophil-To-Lymphocyte Ratioen_US
dc.subjectPlatelet-To-Lymphocyte Ratioen_US
dc.titleThe relationship between inflammation markers and ketonuria in hyperemesis gravidarumen_US
dc.typeArticleen_US

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