Investigation of the Development of Hypersensitivity and Hyperalgesia After Repeated Application of Platelet-Rich Plasma in Rats: An Experimental Study

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dc.contributor.authorInce, Bilsev
dc.contributor.authorYildirim, Mehmet Emin Cem
dc.contributor.authorKilinc, Ibrahim
dc.contributor.authorOltulu, Pembe
dc.contributor.authorDadaci, Mehmet
dc.date.accessioned2024-02-23T14:21:00Z
dc.date.available2024-02-23T14:21:00Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractBackground: Hyperalgesia, defined as hypersensitivity to pain, refers to sensitization of nociceptors to normal levels of pain. Objectives: We aimed to determine whether hyperalgesia occurs due to the development of sensitization following repeated applications of platelet-rich plasma (PRP), and to ascertain the mechanism responsible for inducing hyperalgesia. Methods: This study, performed between 2016 and 2017, involved 32 rats. A 2 cm x 2 cm area was shaved on the back of 10 experimental and 10 sham control animals. In the experimental animals this area was divided into 4 equal squares of 1 cm x 1 cm, and these squares were numbered 1 (no treatment; only the needle was inserted), 2 (0.2 mL, saline), 3 (0.2 mL, nonactivated PRP), and 4 (0.2 mL, activated PRP). The response of the animals to painful stimuli in these areas was investigated with Von Frey filaments, immediately before application and 4 weeks after the last application. Skin biopsies were taken, and growth factors were evaluated pathologically and biochemically. Results: Hyperalgesia developed in all 4 areas of each experimental rat but not in the sham group. However, areas 3 and 4 had smaller Von Frey g values than areas 1 and 2. When growth hormones were assessed histopathologically and biochemically, nerve growth factor (NGF) levels were found to be higher in areas 3 and 4 than in areas 1 and 2 and the sham group. Conclusions: Both nonactivated and activated PRP resulted in greater hypersensitivity than saline and sham treatment. Development of hyperalgesia may be associated with an increase in NGF as well as increased inflammatory mediators.en_US
dc.identifier.doi10.1093/asj/sjz113
dc.identifier.endpage1145en_US
dc.identifier.issn1090-820X
dc.identifier.issn1527-330X
dc.identifier.issue10en_US
dc.identifier.pmid31152170en_US
dc.identifier.scopus2-s2.0-85072233748en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1139en_US
dc.identifier.urihttps://doi.org/10.1093/asj/sjz113
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13401
dc.identifier.volume39en_US
dc.identifier.wosWOS:000491249900027en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Press Incen_US
dc.relation.ispartofAesthetic Surgery Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleInvestigation of the Development of Hypersensitivity and Hyperalgesia After Repeated Application of Platelet-Rich Plasma in Rats: An Experimental Studyen_US
dc.typeArticleen_US

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