PLASMA miR-103 AND miR-107 LEVELS IN OBESE CHILDREN: THE SIGN OF INSULIN RESISTANCE

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dc.contributor.authorTuzlukaya, Tuba
dc.contributor.authorYerlikaya, Fatma Humeyra
dc.contributor.authorCan, Ummu Gulsum
dc.contributor.authorBuyukinan, Muammer
dc.date.accessioned2024-02-23T14:49:18Z
dc.date.available2024-02-23T14:49:18Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractObjective: In this study, it is aimed to research how plasma miR-103 and miR-107 levels are related to insulin resistance changed when comparing obese children to healthy normal-weight children. Material and Method: The study was made on 40 obese children aged 5-17 and with 40 healthy normal-weight children aged 5-17. Plasma miR-103 and miR107 expressions were analyzed using the Real Time-PCR method. Results: miR-103 and miR-107 values about an obese group were significantly found higher (p<0.001) than a control group. It was found a statistically significant level of positive correlation in obese children between miR-103 and body mass index (BMI) (p<0.001) and BMI-p (p<0.01), insulin (p<0.01) and HOMA-IR (p<0.01). Also, it was found the statistically significant level of positive correlation in obese children between miR-107 and BMI (p<0.01), and insulin (p<0.05) ve HOMA-IR (p<0.05). Conclusion: In the light of our findings, we can say that obesity increases plasma miR-103 and miR-107 levels in children and these microRNAs showed a positive correlation with parameter HOMA-IR used to evaluate insulin resistance and insulin. miR-103 and miR-107 can shed impressive progress for understanding glucose homeostasis, whether in normal physiology or human disease.en_US
dc.description.sponsorshipUniversity of Necmettin Erbakan, Scientific Research Projects Department (BAP), Konya-Turkey [151318002]en_US
dc.description.sponsorshipThis research was supported by Grant 151318002 from University of Necmettin Erbakan, Scientific Research Projects Department (BAP), Konya-Turkey.en_US
dc.identifier.endpage11en_US
dc.identifier.issn1305-2381
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage5en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/18113
dc.identifier.volume16en_US
dc.identifier.wosWOS:000530867700001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherNobel Ilacen_US
dc.relation.ispartofNobel Medicusen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObesityen_US
dc.subjectMir-103en_US
dc.subjectMir-107en_US
dc.subjectDiabetesen_US
dc.subjectInsulin Resistanceen_US
dc.titlePLASMA miR-103 AND miR-107 LEVELS IN OBESE CHILDREN: THE SIGN OF INSULIN RESISTANCEen_US
dc.typeArticleen_US

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