Expression of placental growth factor, neuropilin-1, and neuropilin-2 in primary pterygium tissue

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dc.contributor.authorGundogan, Ali Osman
dc.contributor.authorOltulu, Refik
dc.contributor.authorBelviranli, Selman
dc.contributor.authorOltulu, Pembe
dc.date.accessioned2024-02-23T13:43:49Z
dc.date.available2024-02-23T13:43:49Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractPurpose The aim of this study was to evaluate the expression of placental growth factor (PLGF), neuropilin-1 (NP-1), and neuropilin-2 (NP-2) molecules in primary pterygium tissue compared with normal conjunctival tissue.Methods The records of 42 patients who underwent excision surgery with autografts for primary pterygium (pterygium group) and 20 patients who underwent conjunctival nevus excision surgery (control group) in the same period were reviewed retrospectively. The samples obtained from the pterygium tissues in the pterygium group and the clean conjunctival tissues adjacent to the nevus in the control group were collected from the archive. Immunohistochemical stains of the primary antibodies-1/100 diluted PLGF, NP-1, and NP-2 (Abcam Cambridge Science Park, UK)-were applied to all groups. Staining intensities and the percentage of positive cells in epithelial, endothelial, stromal, and inflammatory cells were analyzed by an experienced pathologist.Results The positivity rates of PLGF and NP-2 expression in epithelial, endothelial, stromal, and inflammatory cells were found to be higher in the pterygium group than in the control group (PLGF: p < 0.001, p < 0.001, p = 0.001, and p < 0.001, respectively; NP-2: p < 0.001 for all). Staining intensities for PLGF and NP-2 were higher in the pterygium group than in the control group (PLGF: p < 0.001, p < 0.001, p = 0.005, and p < 0.001, respectively; NP-2: p < 0.001, p < 0.001, p = 0.001, and p < 0.001, respectively). However, no significant differences were found in any cell type in terms of NP-1 expression positivity rates (p = 0.730, p = 0.121, p = 0.524, and p = 0.624, respectively) or staining intensity (p = 0.716, p = 0.147, p = 0.147, and p = 0.780, respectively).Conclusion PLGF and NP-2 levels were found to be higher in pterygium tissue, while there was no difference in NP-1. These results indicate the possible roles of NP-2 and PLGF in primary pterygium.en_US
dc.description.sponsorshipNecmettin Erbakan University Scientific Research Projects Coordination Unit [211518003]en_US
dc.description.sponsorshipThis study was supported by Necmettin Erbakan University Scientific Research Projects Coordination Unit (Project number: 211518003).The work has been done without receiving any financial support from any third party.en_US
dc.identifier.doi10.1007/s00417-023-06280-1
dc.identifier.issn0721-832X
dc.identifier.issn1435-702X
dc.identifier.pmid37878035en_US
dc.identifier.scopus2-s2.0-85174858649en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1007/s00417-023-06280-1
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10935
dc.identifier.wosWOS:001095994800001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofGraefes Archive For Clinical And Experimental Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPlacental Growth Factoren_US
dc.subjectNeuropilin-1en_US
dc.subjectNeuropilin-2en_US
dc.subjectVascular Endothelial Growth Factoren_US
dc.subjectPterygiumen_US
dc.subjectConjunctivaen_US
dc.titleExpression of placental growth factor, neuropilin-1, and neuropilin-2 in primary pterygium tissueen_US
dc.typeArticleen_US

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