Evaluation of the radioprotective effects of thymoquinone on dynamic thiol-disulphide homeostasis during total-body irradiation in rats

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dc.contributor.authorDeniz, Cigdem Damla
dc.contributor.authorAktan, Meryem
dc.contributor.authorErel, Ozcan
dc.contributor.authorGurbilek, Mehmet
dc.contributor.authorKoc, Mehmet
dc.date.accessioned2024-02-23T14:21:01Z
dc.date.available2024-02-23T14:21:01Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractIonizing radiation-induced free radicals cause functional and structural harmful effects. Thiol, an important antioxidant, plays a major role in the eradication of reactive oxygen molecules. Thiol/disulphide homeostasis is a marker of oxidative stress. The objective of this study was to assess the potential radioprotective effects of thymoquinone (TQ) on the dynamic thiol/disulphide homeostasis of rats receiving total-body irradiation (IR). Twenty-two rats were divided into three groups to test the radioprotective effectiveness of TQ. The sham control group did not receive TQ or IR. The IR group received only total-body IR. The TQ + IR group received IR plus TQ. Following IR, blood samples were taken. The thiol/disulphide homeostasis parameters were analysed by a newly established method. In the IR group, native thiol and the native thiol/total thiol ratio were significantly decreased (P = 0.003 and P = 0.003, respectively), whereas the disulphide/native thiol and disulphide/total thiol ratios were significantly increased when compared with those of the sham control group (P = 0.003 and P = 0.003, respectively). In the TQ + IR group, the mean disulphide, native thiol and total thiol levels and the disulphide/native thiol, disulphide/total thiol and native thiol/total thiol ratios were not found to be significantly different when compared with those of the sham control group (P > 0.05 for all). Thiol/disulphide homeostasis was found to be disturbed after IR exposure. The results showed that TQ had antioxidant effects and reduced the IR-induced oxidative stress, which was demonstrated through the dynamic thiol/disulphide homeostasis. Thus, the use of TQ before radiation treatment helped protect the rats from oxidant side effects.en_US
dc.description.sponsorshipNecmettin Erbakan University Scientific Research Coordination Center (BAP) [131218006]en_US
dc.description.sponsorshipThis work was supported by Necmettin Erbakan University Scientific Research Coordination Center (BAP) [grant number: 131218006] for the financial support to this study.en_US
dc.identifier.doi10.1093/jrr/rry083
dc.identifier.endpage28en_US
dc.identifier.issn0449-3060
dc.identifier.issn1349-9157
dc.identifier.issue1en_US
dc.identifier.pmid30358876en_US
dc.identifier.scopus2-s2.0-85061591109en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage23en_US
dc.identifier.urihttps://doi.org/10.1093/jrr/rry083
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13412
dc.identifier.volume60en_US
dc.identifier.wosWOS:000462583100004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofJournal Of Radiation Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDynamic Thiolen_US
dc.subjectDisulphide Homeostasisen_US
dc.subjectIrradiationen_US
dc.subjectThymoquinoneen_US
dc.subjectOxidative Stressen_US
dc.titleEvaluation of the radioprotective effects of thymoquinone on dynamic thiol-disulphide homeostasis during total-body irradiation in ratsen_US
dc.typeArticleen_US

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