Human papillomavirus (HPV) subtypes and their relationships with cervical smear results in cervical cancer screening: a community-based study from the central Anatolia region of Turkey

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dc.contributor.authorFindik, Siddika
dc.contributor.authorFindik, Serkan
dc.contributor.authorAbuoglu, Seyfettin
dc.contributor.authorCihan, Fatma Goksin
dc.contributor.authorIlter, Huseyin
dc.contributor.authorIyisoy, Mehmet Sinan
dc.date.accessioned2024-02-23T14:49:15Z
dc.date.available2024-02-23T14:49:15Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractObjective: Cervical cancer can be diagnosed early by cancer screening programs. The aim of this study was to evaluate the cervical smear test results of healthy women. Methods: We enrolled 94,848 healthy women from 30-65 years of age in whom both HPV typing and a cervical smear test was performed between 2014 and 2017. Results: HPV was detected in 3001 women (3.16%). The mean age was 42 +/- 8.94 years old. Positive HPV types were HPV16; HPV16 and multiple infection; HPV31; HPV51; HPV39; HPV52; HPV56; HPV18; HPV68; HPV35; HPV18 and multiple infection; HPV58; HPV45; HPV59; HPV16, HPV18 and multiple infection; HPV16 and 18; and HPV33, in descending order. Cytology results were normal in 63.61%. We also identified atypical squamous cells of undetermined significance in 6.60%, atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion in 0.73%, low-grade squamous intraepithelial lesion in 10%, high-grade squamous intraepithelial lesion and atypical glandular cells in 0.53%, and adenocarcinoma in situ in 0.03%. In terms of HPV subtypes, abnormal smear results were divided into an HPV16, HPV18, and multiple infection group (25%), an HPV35 group (23.61%), an HPV 16 and multiple infection group (22%), and an HPV16-only group (21.85%). Most cases of HPV (39.02%) and abnormal cytology (43.04%) were detected between the ages of 30 and 40. Conclusions: This study is remarkable because it is a community-based study and includes a large population of healthy women to detect HPV prevalence, its subtype, and abnormal smear results.en_US
dc.identifier.endpage1398en_US
dc.identifier.issn1936-2625
dc.identifier.issue4en_US
dc.identifier.pmid31933954en_US
dc.identifier.startpage1391en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/18062
dc.identifier.volume12en_US
dc.identifier.wosWOS:000466474000028en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal Of Clinical And Experimental Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPapanicolaou Testen_US
dc.subjectHuman Papilloma Virusen_US
dc.subjectPrimary Careen_US
dc.subjectScreeningen_US
dc.titleHuman papillomavirus (HPV) subtypes and their relationships with cervical smear results in cervical cancer screening: a community-based study from the central Anatolia region of Turkeyen_US
dc.typeArticleen_US

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