Characterization of green synthesized flaxseed zinc oxide nanoparticles and their cytotoxic, apoptotic and antimigratory activities on aggressive human cancer cells

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dc.contributor.authorPehlivanoglu, Suray
dc.contributor.authorAcar, Cigdem Aydin
dc.contributor.authorDonmez, Soner
dc.date.accessioned2024-02-23T14:20:45Z
dc.date.available2024-02-23T14:20:45Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractThis study was done of green synthesized zinc oxide nanoparticles (ZnO NPs) by using flaxseed extract (Linum usitatissimum L.) and investigated their potential anticancer effects. The ZnO NPs were characterized by UV-Vis, SEM/EDS, and XRD techniques. These analyses showed that these NPs were spherically shaped with a 23-55 nm size range. The cytotoxicity of NPs was confirmed by MTT assay against A549, HT29, and MDA-MB-231 cancer cells, indicating their antiproliferative effect (IC50 values: 68.3, 66.3, and 58.8 mu g/mL, respectively). The apoptotic induction was analyzed by ELISA, and the results showed that the NPs induced apoptosis through caspase-3/9 activation but not by caspase-8. These NPs significantly trigger the intrinsic-apoptotic pathway. Moreover, they exhibited strong antimigratory properties on the lowly metastatic HT29 and the highly metastatic A549 and MDA-MB-231 cells. This is the first report of Linum usitatissimum L-mediated synthesis of ZnO NPs that could be considered as potential antineoplastic agents.en_US
dc.description.sponsorshipNecmettin Erbakan University Scientific Research Foundation [BAP-161715001]en_US
dc.description.sponsorshipThis study was supported by the Necmettin Erbakan University Scientific Research Foundation (research project No. BAP-161715001).en_US
dc.identifier.doi10.1080/24701556.2021.1980034
dc.identifier.issn2470-1556
dc.identifier.issn2470-1564
dc.identifier.scopus2-s2.0-85115643938en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1080/24701556.2021.1980034
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13290
dc.identifier.wosWOS:000698920500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofInorganic And Nano-Metal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGreen Synthesisen_US
dc.subjectFlaxseed Zinc Oxide Nanoparticlesen_US
dc.subjectMetastatic Cancer Cellsen_US
dc.subjectApoptoticen_US
dc.subjectAntiproliferative And Antimigratory Activitiesen_US
dc.titleCharacterization of green synthesized flaxseed zinc oxide nanoparticles and their cytotoxic, apoptotic and antimigratory activities on aggressive human cancer cellsen_US
dc.typeArticleen_US

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