Protective Effects of Biochanin A against Methotrexate-Induced Acute Liver Injury in Rats

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dc.contributor.authorOzer, Erdem Kamil
dc.contributor.authorGoktas, Mustafa Tugrul
dc.contributor.authorToker, Aysun
dc.contributor.authorUgurluoglu, Ceyhan
dc.contributor.authorBariskaner, Hulagu
dc.date.accessioned2024-02-23T14:41:43Z
dc.date.available2024-02-23T14:41:43Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractBackground: Methotrexate (MTX) is one of the most commonly used chemotherapeutic agents in the treatment of cancer patients, however its therapeutic use is limited due to dose dependent hepatotoxicity caused by oxidative damage. Biochanin A (BCA), a naturally occurring dietary isoflavone, has strong cytoprotective, anti-inflammatory, and antioxidant properties. Although protective actions of BCA against various chemical-induced hepatotoxicity including that of carbon tetrachloride and arsenic, none of the studies was made on MTX-induced acute liver injury. Methods: Wistar rats were separated into four groups; Control, MTX, Control+BCA, MTX+BCA. BCA (50 mg/kg/day) or vehicle (dimethyl sulfoxide; 1 mL/kg/day) with the same volume was intraperitoneally injected for 5 days. At sixth day, a single dose of MTX (20 mg/kg) was injected to rats. Twenty-four h after the MTX administration, rats were sacrificed and then blood and liver samples were obtained for biochemical and histopathologic analyses. Results: MTX increased the serum AST, ALT, and LDH levels. Furthermore, malondialdehyde (an indicator of oxidative injury) and myeloperoxidase (an indicator of neutrophil infiltration) levels increased, while total glutathione levels (an indicator of antioxidant status) decreased in liver. MTX-induced hepatotoxicity was also observed histopathologically. BCA substantially improved these alterations induced by MTX administration. Conclusion: These results indicate that BCA may be useful in preventing the MTX-induced acute liver injury due to its antioxidant and anti-inflammatory properties.en_US
dc.identifier.doi10.5530/ijper.51.4s.107
dc.identifier.endpageS746en_US
dc.identifier.issn0019-5464
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85041704314en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpageS741en_US
dc.identifier.urihttps://doi.org/10.5530/ijper.51.4s.107
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16953
dc.identifier.volume51en_US
dc.identifier.wosWOS:000435144400029en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAssoc Pharmaceutical Teachers Indiaen_US
dc.relation.ispartofIndian Journal Of Pharmaceutical Education And Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMethotrexateen_US
dc.subjectHepatotoxicityen_US
dc.subjectBiochanin Aen_US
dc.subjectProtective Effectsen_US
dc.titleProtective Effects of Biochanin A against Methotrexate-Induced Acute Liver Injury in Ratsen_US
dc.typeArticleen_US

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