New copper(II) complex based-thiosemicarbazone and phenanthroline: DNA/BSA binding, antiproliferative activity, DFT and docking studies

Basit Öğe Kaydı
dc.contributor.authorFindik, Mukerrem
dc.contributor.authorTurkkan, Ercan
dc.contributor.authorPehlivanoglu, Suray
dc.contributor.authorSayin, Ulku
dc.contributor.authorCeylan, Umit
dc.contributor.authorAkgemci, Emine Guler
dc.date.accessioned2024-02-23T14:03:16Z
dc.date.available2024-02-23T14:03:16Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractA new copper(II) complex {Cu(HPP)}, bromo(1,10-phenanthroline)(triphenylphosphine)copper(I) with 2-hydroxy-5-methoxyacetophenone thiosemicarbazone (HMAT) was synthesized and characterized by experimental FT-IR, Raman, UV-vis, TGA and EPR spectral analysis. The Cu(HPP) was theoretically modeled using the B3LYP/VTZ method/basis set and the values of the spectroscopic parameters were calculated by the DFT method. The coordination geometry around the Cu(II) in the compound was predicted as an elongated octahedral. Spectroscopic investigations showed the intercalative binding mechanism of the Cu(HPP) with calf-thymus deoxyribonucleic acid (ct-DNA). Spectroscopic techniques were also used to evaluate the interaction of the Cu (HPP) with bovine serum albumin (BSA), which revealed that the Cu(HPP) could bind to BSA significantly. In addition, the molecular docking between the Cu(HPP) and BSA was investigated to support the bonding mechanism. Further, we studied the anticancer activity of the Cu(HPP) in drug resistant breast cancer cell line (MDA-MB-231), with a focus on the proliferative characteristics. Our findings emphasize that this newly synthetized complex has a significant cytotoxic effect on the cells and can be utilized as a candidate chemotherapeutic agent to effectively target breast cancer.en_US
dc.identifier.doi10.1016/j.inoche.2023.111300
dc.identifier.issn1387-7003
dc.identifier.issn1879-0259
dc.identifier.scopus2-s2.0-85169794836en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.inoche.2023.111300
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12046
dc.identifier.volume156en_US
dc.identifier.wosWOS:001066906800001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInorganic Chemistry Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThiosemicarbazoneen_US
dc.subjectCu(Ii) Complexen_US
dc.subjectDften_US
dc.subjectDockingen_US
dc.subjectEpren_US
dc.subjectDna/Bsa Bindingen_US
dc.subjectAntiproliferative Activityen_US
dc.titleNew copper(II) complex based-thiosemicarbazone and phenanthroline: DNA/BSA binding, antiproliferative activity, DFT and docking studiesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu