Relationship between Plasma Pentraxin-3, Neutrophil-to-Lymphocyte Ratio, and Atherosclerosis in Renal Transplant Patients

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dc.contributor.authorTurkmen, Kultigin
dc.contributor.authorErdur, Fatih Mehmet
dc.contributor.authorGuney, Ibrahim
dc.contributor.authorOzbiner, Huseyin
dc.contributor.authorToker, Aysun
dc.contributor.authorGaipov, Abduzhappar
dc.contributor.authorOzbek, Orhan
dc.date.accessioned2024-02-23T14:26:39Z
dc.date.available2024-02-23T14:26:39Z
dc.date.issued2012
dc.departmentNEÜen_US
dc.description.abstractBackground/Aims: Atherosclerosis and inflammation are the most important risk factors in the pathogenesis of cardiovascular diseases (CVD) in patients with end-stage renal disease (ESRD). Pentraxin-3 (PTX-3) was shown to predict inflammation and atherosclerosis in ESRD patients. However, the role of renal transplantation (Rtx) in terms of atherogenesis is still unclear. We aimed to investigate the relationship between PTX-3, neutrophil-to-lymphocyte ratio (NLR), and carotid intima-media thickness (CIMT) in Rtx patients and healthy controls. Methods: This was a cross-sectional study involving 29 Rtx patients (12 females, 40.1 +/- 11.9 years) without overt CVD and 19 healthy subjects (9 females, 36.9 +/- 8.9 years), testing the relationship between CIMT, assessed by ultrasonography, and selected biomarkers. Results: CIMT, PTX-3, and high-sensitivity C-reactive protein (hs-CRP) levels of Rtx patients were found to be significantly higher compared to healthy subjects. CIMT was positively correlated with age, creatinine, uric acid, triglyceride, PTX-3, hs-CRP, and NLR, and negatively correlated with estimated glomerular filtration rate in all participants. In Rtx patients, CIMT was positively correlated with age, BMI, serum phosphorus, low-density lipoprotein, and hs-CRP. The multivariate analysis revealed that hs-CRP was found to be an independent variable of CIMT in Rtx patients. Conclusion: Our data showed that inflammation and atherosclerosis persist in Rtx patients. Serum hs-CRP might be a useful marker to assess these parameters in this population. Copyright (C) 2012 S. Karger AG, Baselen_US
dc.description.sponsorshipERA-EDTA fellowship programen_US
dc.description.sponsorshipDr. A. Gaipov received grant support from the ERA-EDTA fellowship program.en_US
dc.identifier.doi10.1159/000343887
dc.identifier.endpage307en_US
dc.identifier.issn1664-3828
dc.identifier.issue4en_US
dc.identifier.pmid23380985en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage298en_US
dc.identifier.urihttps://doi.org/10.1159/000343887
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14266
dc.identifier.volume2en_US
dc.identifier.wosWOS:000312685600006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofCardiorenal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPentraxin-3en_US
dc.subjectNeutrophil-To-Lymphocyte Ratioen_US
dc.subjectHigh-Sensitivity C-Reactive Proteinen_US
dc.subjectCarotid Intima-Media Thicknessen_US
dc.subjectRenal Transplantationen_US
dc.titleRelationship between Plasma Pentraxin-3, Neutrophil-to-Lymphocyte Ratio, and Atherosclerosis in Renal Transplant Patientsen_US
dc.typeArticleen_US

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