Effects of agomelatine on electrocorticogram activity on penicillin-induced seizure model of rats

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dc.contributor.authorEthemoglu, M. S.
dc.contributor.authorKutlu, S.
dc.contributor.authorSeker, F. B.
dc.contributor.authorErdogan, C. S.
dc.contributor.authorBingol, C. A.
dc.contributor.authorYilmaz, B.
dc.date.accessioned2024-02-23T14:13:19Z
dc.date.available2024-02-23T14:13:19Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractAgomelatine is a new antidepressant drug acting as an antagonist of 5-hydroxytryptamine receptor 2C (5-HTR2c) and agonist of melatonergic receptors 1 and 2 (MT1 and MT2). Because of this dual action, it is an atypical antidepressant. The aim of this study was to investigate chronic anticonvulsant effects of agomelatine on penicillin-induced epilepsy model. Adult male Sprague Dawley rats divided into four groups and were administered with tap water (vehicle), and agomelatine doses of 10 mg/kg, 50 mg/kg and 100 mg/kg for 14 days via oral gavage. After the last doses were given, epileptic seizures were induced by intracortical penicillin (500 IU/2.5 mu l) application in rats under urethane (1.25 g/kg intraperitoneal) anesthesia. Electrocorticogram (ECoG) recordings were obtained from the somatomotor cortex through 90 min, and spike frequencies and amplitudes were analyzed. The spike frequency analyses revealed that only 50 mg/kg agomelatine administration decreased the spike frequencies of hypersynchronous discharge of neurons caused by penicillin (p < 0.05). No significant differences in amplitudes between experimental groups were observed. In addition, mRNA expressions of vesicular glutamate transporter 1 (VGLUT1) and vesicular gamma-aminobutyric acid transporter (VGAT) in response to the agomelatine active dose, 50 mg/kg, showed no significant effect of agomelatine on the mRNA expression. Our results indicate that chronic treatment with agomelatine may have potential anticonvulsant effects. Agomelatine may be a promising drug for epilepsy patients having depression due to its antiepileptic and antidepressant effects.en_US
dc.description.sponsorshipYeditepe University, Turkey; Necmettin Erbakan University Research Foundation, Turkey [BAP141318006]en_US
dc.description.sponsorshipThis study was supported by Yeditepe University, Turkey and Necmettin Erbakan University Research Foundation (Project Number: BAP141318006), Turkey.en_US
dc.identifier.doi10.1016/j.neulet.2018.09.014
dc.identifier.endpage125en_US
dc.identifier.issn0304-3940
dc.identifier.issn1872-7972
dc.identifier.pmid30213622en_US
dc.identifier.scopus2-s2.0-85055119431en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage120en_US
dc.identifier.urihttps://doi.org/10.1016/j.neulet.2018.09.014
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12388
dc.identifier.volume690en_US
dc.identifier.wosWOS:000456752500020en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAgomelatineen_US
dc.subjectSeizureen_US
dc.subjectElectrocorticogramen_US
dc.subjectPenicillin-Induced Seizureen_US
dc.titleEffects of agomelatine on electrocorticogram activity on penicillin-induced seizure model of ratsen_US
dc.typeArticleen_US

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