Are Pattern Recognition Receptors Associated with Hepatocellular Carcinoma?

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dc.contributor.authorDertli, Ramazan
dc.contributor.authorAsil, Mehmet
dc.contributor.authorBiyik, Murat
dc.contributor.authorKarakarcayildiz, Ahmet
dc.contributor.authorKeskin, Muharrem
dc.contributor.authorKayar, Yusuf
dc.contributor.authorBasdemirci, Muserref
dc.date.accessioned2024-02-23T14:41:17Z
dc.date.available2024-02-23T14:41:17Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractBackground: Hepatocellular carcinoma (HCC) is one of the important causes of mortality due to malignancy. Toll-like receptors (TLRs) are very important in liver pathophysiology in terms of their roles in the innate immune system, such as the regulation of inflammation, wound healing, stimulation of adaptive immune responses, promotion of epithelial regeneration, and carcinogenesis. In this study, we planned to examine the role of TLR1 (rs4833095, rs5743551) and nucleotide-binding oligomerization domain (NOD2) (rs2066844, rs2066845, rs2066847) polymorphisms in the development of HCC and their effects on the clinical presentation of HCC patients. Methods: Our study was designed prospectively. Cirrhotic and HCC patients who were followed up in our clinic between January 2015 and September 2018 were included in the study. Sex, age, cirrhosis etiology, Child-Pugh class, and MELD scores were recorded. TLR1 and NOD2 polymorphisms were studied by the PCR method. Results: HCC developed in 88 (31.4%) of the 280 patients who were followed up, either during the recruitment phase of our study or during the follow-up. The mean follow-up time of our patient group was 17.04 +/- 11.72 months, and the mean follow-up time of HCC patients was 12.09 +/- 10.26 months. TLR1 (rs5743551) polymorphism was associated with HCC development (P =.003). TLR1 (rs5743551) and NOD2 (rs2066844) polymorphisms were associated with the development of spontaneous bacterial peritonitis (SBP) in the HCC patient group (P =.013 and P =.021, respectively). Conclusion: We think that increased bacterial translocation in cirrhotic patients may contribute to HCC development by causing chronic inflammation, especially in patients with TLR 1 (rs5743551) polymorphism.en_US
dc.identifier.doi10.5152/tjg.2021.20657
dc.identifier.endpage599en_US
dc.identifier.issn2148-5607
dc.identifier.issue7en_US
dc.identifier.pmid34464323en_US
dc.identifier.scopus2-s2.0-85114149894en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage593en_US
dc.identifier.urihttps://doi.org/10.5152/tjg.2021.20657
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16778
dc.identifier.volume32en_US
dc.identifier.wosWOS:000692559500007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal Of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectToll-Like Receptorsen_US
dc.subjectNucleotide-Binding Oligomerization Domainen_US
dc.subjectHepatocellular Carcinomaen_US
dc.subjectSpontaneous Bacterial Peritonitisen_US
dc.titleAre Pattern Recognition Receptors Associated with Hepatocellular Carcinoma?en_US
dc.typeArticleen_US

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