Nephrological factors may cause kidney dysfunction in patients with common variable immunodeficiency

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dc.contributor.authorAytekIn, Gokhan
dc.contributor.authorBaloglu, Ismail
dc.contributor.authorColkesen, Fatih
dc.contributor.authorYildiz, Eray
dc.contributor.authorArslan, Sevket
dc.contributor.authorTurkmen, Kultigin
dc.date.accessioned2024-02-23T14:37:24Z
dc.date.available2024-02-23T14:37:24Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractBackground/aim: Common variable immunodeficiency (CVID) is a heterogeneous primary deficiency characterized by hypogammaglobulinemia, recurrent infections, an increased risk of autoimmune disease, malignancy, and chronic inflammation. Proteinuria is one of the most important prognostic factors causing progression in kidney disease. Proteinuria causes tubulotoxicity, activates inflammatory markers that cause fibrosis, and consequently nephropathy progression. The data is scant in the literature regarding the inflammation and nephropathy in CVID. Hence, in the present study, we aimed to investigate the relationship between tubular dysfunction, proteinuria, and inflammation in patients with CVID. Materials and methods: This was a cross-sectional study involving 27 patients with CVID (15 females, 12 males; mean age, 39.88 +/- 13.47 years) and 18 control subjects (10 females, 8 males; mean age, 33.83 +/- 7.97 years). Patients were evaluated for kidney functions including glomerular filtration rate, fractional excretion of sodium, metabolic acidosis, serum/urine anion gap, 24-h urine proteinuria and, were grouped in terms of proteinuria. Blood samples obtained from the patients with CVID were taken into 2 mL EDTA tube to evaluate peripheral NK cell subgroups according to CD56 and CD16 expression and CD3, CD4, CD 8 expression to determine subtypes T cells. These cells were evaluated by flow cytometry technique. Results: Urinary density, fractional excretion of sodium, proteinuria, and metabolic acidosis are found to be higher in patients with CVID when compared to healthy controls. In the bivariate correlation analysis, proteinuria was positively correlated with age (r = 0.496, p = < 0.001), CD8+T cells percentage (r = 0.427, p = 0.02). Albumin, CRP, and CD8+T cell percentage were found to be independent variables of proteinuria. Conclusion: Increased chronic ongoing inflammation was found to be associated with proteinuria in patients with CVID. Hence, in routine outpatient clinics, proteinuria should not be overlooked in this group of patients.en_US
dc.identifier.doi10.3906/sag-2012-166
dc.identifier.endpage1931en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue4en_US
dc.identifier.pmid33843169en_US
dc.identifier.scopus2-s2.0-85114266158en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1924en_US
dc.identifier.urihttps://doi.org/10.3906/sag-2012-166
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16093
dc.identifier.volume51en_US
dc.identifier.wosWOS:000691544700043en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChronic Inflammationen_US
dc.subjectProteinuriaen_US
dc.subjectCommon Variable Immunodeficiencyen_US
dc.titleNephrological factors may cause kidney dysfunction in patients with common variable immunodeficiencyen_US
dc.typeArticleen_US

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