Biological correlates of major depression and generalized anxiety disorder in women with polycystic ovary syndrome

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dc.contributor.authorAnnagur, Bilge Burcak
dc.contributor.authorTazegul, Aybike
dc.contributor.authorUguz, Faruk
dc.contributor.authorKerimoglu, Ozlem Secilmis
dc.contributor.authorTekinarslan, Emine
dc.contributor.authorCelik, Cetin
dc.date.accessioned2024-02-23T14:13:02Z
dc.date.available2024-02-23T14:13:02Z
dc.date.issued2013
dc.departmentNEÜen_US
dc.description.abstractObjective: We aimed to compare the levels of serum androgens in women with polycystic ovary syndrome (PCOS) who had a diagnosis of only major depressive disorder (MDD), only generalized anxiety disorder (GAD) or who had no psychiatric disorder, as determined by a structured clinical interview. Another objective of the study was to examine whether an association exists between these psychiatric diagnoses and insulin resistance or body mass index via a comparison among the study groups in terms of these parameters. Method: This study was performed between March 2011 and February 2012. A total of 73 patients were included in the study. The study sample consisted of three groups: PCOS patients with only major depressive disorder (n = 23), PCOS patients with only generalized anxiety disorder (n = 20), and PCOS patients without any diagnosed psychiatric disorders (not diagnosed - ND group, n = 30). Results: Significant difference was found among the three groups with regard to the serum levels of 17-OHP and DHEAS. When multiple comparisons were performed among the groups, 17-OHP levels were significantly higher in the MDD group than in the ND group. DHEAS levels were significantly higher in the MDD group and the GAD group than in the ND group. Conclusion: The present study suggests that MDD and GAD appear to be associated with higher DHEAS levels. (C) 2013 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jpsychores.2013.01.002
dc.identifier.endpage247en_US
dc.identifier.issn0022-3999
dc.identifier.issn1879-1360
dc.identifier.issue3en_US
dc.identifier.pmid23438716en_US
dc.identifier.scopus2-s2.0-84874262818en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage244en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpsychores.2013.01.002
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12266
dc.identifier.volume74en_US
dc.identifier.wosWOS:000315548600011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofJournal Of Psychosomatic Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDepressionen_US
dc.subjectGeneralized Anxiety Disorderen_US
dc.subjectHyperandrogenismen_US
dc.subjectPolycystic Ovary Syndromeen_US
dc.titleBiological correlates of major depression and generalized anxiety disorder in women with polycystic ovary syndromeen_US
dc.typeArticleen_US

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