Association of Cytotoxic T Lymphocyte Antigen-4 Gene Polymorphisms with Psoriasis Vulgaris: A Case-Control Study in Turkish Population

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dc.contributor.authorDursun, Hatice Gul
dc.contributor.authorYilmaz, Huseyin Osman
dc.contributor.authorDursun, Recep
dc.contributor.authorKulaksizoglu, Sevsen
dc.date.accessioned2024-02-23T14:26:32Z
dc.date.available2024-02-23T14:26:32Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractPsoriasis is a common, chronic, and autoimmune skin disease in which dysregulation of immune cells, particularly T cells, is thought to play an important role in the pathogenesis. Cytotoxic T lymphocyte antigen-4 (CTLA-4) expressed only on activated T cells is an immunoregulatory molecule and plays a role in the pathogenesis of autoimmune disorders. We aimed to determine whether CTLA-4 gene polymorphisms are associated with development and/or clinical features of psoriasis vulgaris (Pv). Genotyping of SNPs (-318C>T, +49A>G, and CT60A>G) in CTLA-4 gene was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 103 Pv patients and 102 controls. No statistically significant associations were detected in any of the investigated genetic models for the -318C>T polymorphism. The genotype distributions of +49A>G and CT60A>G were associated with Pv development. In haplotype analysis, while frequency of CAA haplotype was significantly higher in the control group, frequencies of CGG and CAG haplotype were significantly higher among the patients. However, all of CTLA-4 polymorphisms and haplotypes do not have an effect on severity and onset age of Pv. In conclusion, the +49A>G and CT60A>G polymorphisms may be risk factors for Pv development. Furthermore, CGG and CAG haplotypes may contribute to Pv development, while CAA haplotype may be protective against Pv.en_US
dc.description.sponsorshipScientific Research Project Unit of Selcuk University [10202049]en_US
dc.description.sponsorshipThis study was supported by Grant no. 10202049 from the Scientific Research Project Unit of Selcuk University.en_US
dc.identifier.doi10.1155/2018/1643906
dc.identifier.issn2314-8861
dc.identifier.issn2314-7156
dc.identifier.pmid29850619en_US
dc.identifier.scopus2-s2.0-85054720928en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1155/2018/1643906
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14237
dc.identifier.volume2018en_US
dc.identifier.wosWOS:000431582100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofJournal Of Immunology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleAssociation of Cytotoxic T Lymphocyte Antigen-4 Gene Polymorphisms with Psoriasis Vulgaris: A Case-Control Study in Turkish Populationen_US
dc.typeArticleen_US

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