Decreased plasma intercellular adhesion molecule-3 levels are associated with obsessive compulsive disorder in medication-free children

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dc.contributor.authorBilgic, Ayhan
dc.contributor.authorIleri, Betul Akbas
dc.contributor.authorKilinc, Ibrahim
dc.contributor.authorAkca, Omer Faruk
dc.date.accessioned2024-02-23T14:12:54Z
dc.date.available2024-02-23T14:12:54Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractThe objective of this study was to evaluate whether the plasma levels of soluble intercellular adhesion molecule-1 (sICAM-1), intercellular adhesion molecule-3 (sICAM-3), vascular cell adhesion molecule-1 (sVCAM-1), and/or platelet endothelial cell adhesion molecule-1 (sPECAM-1) were associated with obsessive compulsive disorder (OCD) in childhood. A total of 42 (25 boys, 17 girls) medication-free children with OCD and 38 (18 boys, 20 girls) healthy controls aged 8-18 years were included in the study. The severity of the OCD symptoms was assessed using the Children's Yale-Brown Obsessive Compulsive Scale. The Children's Depression Inventory and the Screen for Child Anxiety-Related Emotional Disorders were used to measure the children's depression and anxiety levels. The sICAM-1, sICAM-3, sVCAM-1, and sPECAM-1 concentrations were measured using an enzyme-linked immunosorbent assay. A multivariate analysis of covariance revealed a significant main effect on both groups in terms of the concentrations of plasma adhesion molecules, which was independent of the severities of depression and anxiety, body mass index percentile, age, and sex. An analysis of covariance showed that plasma sICAM-3 concentrations were significantly lower in the OCD group than in the control group. These data suggest that sICAM-3 may play a role in the etiopathogenesis of OCD in children.en_US
dc.description.sponsorshipScientific Research Project Coordination Unit of Necmettin Erbakan University [181218015]en_US
dc.description.sponsorshipFunding for this study was provided by a grant from the Scientific Research Project Coordination Unit of Necmettin Erbakan University (Project Number: 181218015). The Scientific Research Project Coordination Unit of Necmettin Erbakan University had no role in the study design, collection, analysis or interpretation of the data, writing the manuscript, or the decision to submit the paper for publication.en_US
dc.identifier.doi10.1016/j.jocrd.2020.100581
dc.identifier.issn2211-3649
dc.identifier.issn2211-3657
dc.identifier.scopus2-s2.0-85090734266en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.jocrd.2020.100581
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12238
dc.identifier.volume27en_US
dc.identifier.wosWOS:000591950000022en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal Of Obsessive-Compulsive And Related Disordersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObsessive Compulsive Disorderen_US
dc.subjectIntercellular Adhesion Molecule-1en_US
dc.subjectIntercellular Adhesion Molecule-3en_US
dc.subjectVascular Cell Adhesion Molecule-1en_US
dc.subjectPlatelet Endothelial Cell Adhesion Molecule-1en_US
dc.titleDecreased plasma intercellular adhesion molecule-3 levels are associated with obsessive compulsive disorder in medication-free childrenen_US
dc.typeArticleen_US

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