The Use of Antidepressant Medications During Pregnancy and the Risk of Neonatal Seizures A Systematic Review

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dc.contributor.authorUguz, Faruk
dc.date.accessioned2024-02-23T14:21:11Z
dc.date.available2024-02-23T14:21:11Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractPurpose This review examined the current literature about the potential relationship between the use of antidepressants during pregnancy and neonatal seizures. Methods PubMed was searched for English language reports published between January 1, 1996, and October 31, 2018, by using combinations of the following key words: pregnancy, neonatal outcome, neonatal convulsion, neonatal seizure, SSRI, selective serotonin norepinephrine reuptake inhibitor (SNRI), tricyclic antidepressant (TCA), antidepressants, sertraline, fluoxetine, paroxetine, citalopram, escitalopram, fluvoxamine, venlafaxine, mirtazapine, duloxetine, bupropion, amitriptyline, imipramine, and clomipramine. Findings A total of 9 relevant studies that met the review criteria were examined. The prevalence rates of neonatal seizures in the antidepressant groups and control groups were 0.30% to 0.91% and 0.10% to 0.30%, respectively. The use of selective serotonin reuptake inhibitors was associated with up to 5-fold increase in the risk of neonatal seizures. Compared with the controls, higher risks were reported in newborns of pregnant women using any antidepressant or tricyclic antidepressants albeit in a limited number of studies. Exposure to antidepressants in the third trimester of pregnancy appeared to be associated more with neonatal seizures compared with earlier exposure. Implicatons Although an increased risk of neonatal seizures in newborns antenatally exposed to antidepressants especially selective serotonin reuptake inhibitors may be suggested, the available studies have severe methodological limitations to enable any firm conclusion.en_US
dc.identifier.doi10.1097/JCP.0000000000001093
dc.identifier.endpage484en_US
dc.identifier.issn0271-0749
dc.identifier.issn1533-712X
dc.identifier.issue5en_US
dc.identifier.pmid31425466en_US
dc.identifier.scopus2-s2.0-85071624908en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage479en_US
dc.identifier.urihttps://doi.org/10.1097/JCP.0000000000001093
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13482
dc.identifier.volume39en_US
dc.identifier.wosWOS:000486170600010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal Of Clinical Psychopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntidepressantsen_US
dc.subjectNeonatal Seizuresen_US
dc.subjectPregnancyen_US
dc.subjectNeonatal Outcomesen_US
dc.titleThe Use of Antidepressant Medications During Pregnancy and the Risk of Neonatal Seizures A Systematic Reviewen_US
dc.typeReview Articleen_US

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