Role of thiol-disulfide hemostasis in early diagnosis of acute mesentery ischemia: An experimental study

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dc.contributor.authorYildirim, Mehmet Aykut
dc.contributor.authorKocabas, Rahim
dc.contributor.authorKilinc, Ibrahim
dc.contributor.authorSimsek, Gurcan
dc.contributor.authorSenturk, Mustafa
dc.contributor.authorCakir, Murat
dc.contributor.authorBelviranli, Metin
dc.date.accessioned2024-02-23T14:31:41Z
dc.date.available2024-02-23T14:31:41Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractBACKGROUND: Acute mesenteric ischemia (AMI) is a rarely observed acute abdominal disease that may be mortal and is difficult to diagnose early. The aim of our study is to assess the role of Thiol-Disulphide Haemostasis (TDH), a new method for AMI which still has no specific biochemical markers for early diagnosis, and to assess it together with Ischemia-Modified Albumin (IMA) which METHODS: The study included 32 Wistar albino rats in four groups. The 1st group (n=8) was the control group, 2nd group (n=8) was the sham group, 3rd group (n=8) had 3 h of arterial mesentery ischemia and the 4th group (n=8) had 6 h of arterial mesentery ischemia. RESULTS: In the 3rd and 6th h, serum total thiol and native thiol values significantly reduced (p<0.001), while serum disulfide, IMA, and lactate values clearly increased (p<0.001). Serum thiol values were observed to reduce from the 1st h. CONCLUSION: TDH changes in the early period of AMI. The TDH parameters can be used with IMA as diagnostic parameters for patients with suspected AMI in the early period.en_US
dc.identifier.doi10.14744/tjtes.2020.44025
dc.identifier.endpage410en_US
dc.identifier.issn1306-696X
dc.identifier.issn1307-7945
dc.identifier.issue4en_US
dc.identifier.pmid35485506en_US
dc.identifier.scopus2-s2.0-85128448531en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage403en_US
dc.identifier.urihttps://doi.org/10.14744/tjtes.2020.44025
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15311
dc.identifier.volume28en_US
dc.identifier.wosWOS:000781192000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Assoc Trauma Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal Of Trauma & Emergency Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute Mesentery Ischemiaen_US
dc.subjectDisulfideen_US
dc.subjectHemostasisen_US
dc.subjectThiolen_US
dc.titleRole of thiol-disulfide hemostasis in early diagnosis of acute mesentery ischemia: An experimental studyen_US
dc.typeArticleen_US

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