The Adiponectin variants contribute to the genetic background of type 2 diabetes in Turkish population

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dc.contributor.authorArikoglu, Hilal
dc.contributor.authorOzdemir, Hulya
dc.contributor.authorKaya, Dudu Erkoc
dc.contributor.authorIpekci, Suleyman Hilmi
dc.contributor.authorArslan, Ahmet
dc.contributor.authorKayis, Seyit Ali
dc.contributor.authorGonen, Mustafa Sait
dc.date.accessioned2024-02-23T14:02:58Z
dc.date.available2024-02-23T14:02:58Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractAdiponectin, an adipose tissue specific protein encoded by the Adiponectin gene, modulates insulin sensitivity and plays an important role in regulating energy homeostasis. Many studies have shown that single nucleotide polymorphisms (SNPs) in the Adiponectin gene are associated with low plasma Adiponectin levels, insulin resistance and an increased risk of type 2 diabetes mellitus. The aim of the present study was to evaluate the contribution of the Adiponectin gene polymorphisms in genetic background of type 2 diabetes in a Turkish population. In total, 169 unrelated and non-obese diabetic patients and 119 age- and BMI-matched nondiabetic individuals with no family history of diabetes were enrolled in this study. We detected a significant association between type 2 diabetes and two SNPs: SNP - 11391G>A. which is located in the promoter region of the Adiponectin gene, and SNP + 276G > T, which is found in intron 2 of the gene (P < 0.05). The silence SNP G15G ( + 45T > G) in exon 1 and SNP + 349A > G in intron 2 also showed a weak association with type 2 diabetes (P = 0.06 and P = 0.07, respectively), while SNPs - 3971A>G in intron 1 and Y111H, R112C and H241P in exon 3 showed no association (P > 0.05). In conclusion, these findings suggest that Adiponectin gene polymorphisms might be effective on susceptibility for type 2 diabetes development which emerged from the interactions between multiple genes, variants and environmental factors. (C) 2013 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipSelcuk University Research Foundation [09401029]en_US
dc.description.sponsorshipWe would like to thank to Dr Melda Aksoy Hepdogru, Dr Elif Turan and Dr Fazilet Cankaya, Sevgi Bozkurt and Dr Onur Ozturk for their assistance in this study. This study was supported by the Selcuk University Research Foundation (09401029).en_US
dc.identifier.doi10.1016/j.gene.2013.10.039
dc.identifier.endpage16en_US
dc.identifier.issn0378-1119
dc.identifier.issn1879-0038
dc.identifier.issue1en_US
dc.identifier.pmid24404592en_US
dc.identifier.scopus2-s2.0-84888037570en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage10en_US
dc.identifier.urihttps://doi.org/10.1016/j.gene.2013.10.039
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11920
dc.identifier.volume534en_US
dc.identifier.wosWOS:000328183700002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofGeneen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdiponectin Geneen_US
dc.subjectSingle Nucleotide Polymorphismen_US
dc.subjectType 2 Diabetesen_US
dc.titleThe Adiponectin variants contribute to the genetic background of type 2 diabetes in Turkish populationen_US
dc.typeArticleen_US

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