Effects of garlic oil (allium sativum) on acetic acid-induced colitis in rats: Garlic oil and experimental colitis

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dc.contributor.authorTanrikulu, Yusuf
dc.contributor.authorSen Tanrikulu, Ceren
dc.contributor.authorKilinc, Fahriye
dc.contributor.authorCan, Murat
dc.contributor.authorKokturk, Furuzan
dc.date.accessioned2024-02-23T14:29:39Z
dc.date.available2024-02-23T14:29:39Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractBACKGROUND: Inflammatory bowel disease (IBD) is an important health problem. The most important hypotheses for the pathogenesis of this disease are the deterioration of immune responses and loss of tolerance against bacteria in the enteric flora. Although IBD has been widely investigated, its treatment remains difficult. This study aims to investigate the effects of garlic oil (GO) on an experimental colitis model. METHODS: Twenty-eight rats were randomly divided into four equal groups as follows: group 1 (sham), group 2 (control), group 3 (topical treatment) and group 4 (topical and systemic treatment). An acetic acid-induced colitis model was produced in groups 2, 3 and 4 and was administered normal saline, topical GO and topical and systemic GO, respectively. RESULTS: Hydroxyproline levels were lower in the treatment groups than in the control group. TNF-alpha levels were significantly lower in group 3 than in group 2. Macroscopic scores were significantly lower in group 4 than in group 2. Significant differences were observed between the treatment and control groups according to their epithelial loss. CONCLUSION: GO can reduce colonic damage and inflammation in the acetic acid-induced colitis model, with effects on both local and systemic treatments, but with a more pronounced effect in local treatment.en_US
dc.identifier.doi10.14744/tjtes.2019.01284
dc.identifier.endpage508en_US
dc.identifier.issn1306-696X
dc.identifier.issue4en_US
dc.identifier.pmid32589234en_US
dc.identifier.scopus2-s2.0-85087165778en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage503en_US
dc.identifier.urihttps://doi.org/10.14744/tjtes.2019.01284
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14806
dc.identifier.volume26en_US
dc.identifier.wosWOS:000580593100002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Assoc Trauma Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal Of Trauma & Emergency Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcetic Aciden_US
dc.subjectColitisen_US
dc.subjectDiallyl Sulphideen_US
dc.subjectGarlic Oilen_US
dc.subjectInflammatory Bowel Diseaseen_US
dc.subjectTnf-Alphaen_US
dc.titleEffects of garlic oil (allium sativum) on acetic acid-induced colitis in rats: Garlic oil and experimental colitisen_US
dc.typeArticleen_US

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