Apoptosis-induced T-cell lymphopenia is related to COVID-19 severity

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dc.contributor.authorCizmecioglu, Ahmet
dc.contributor.authorCizmecioglu, Hilal Akay
dc.contributor.authorGoktepe, Mevlut Hakan
dc.contributor.authorEmsen, Ayca
dc.contributor.authorKorkmaz, Celalettin
dc.contributor.authorTasbent, Fatma Esenkaya
dc.contributor.authorConsultant, Fatma Colkesen
dc.date.accessioned2024-02-23T12:16:52Z
dc.date.available2024-02-23T12:16:52Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractIncreased levels of acute-phase reactants and lymphopenia are predictors of disease severity in coronavirus disease 2019 (COVID-19). This study aimed to investigate the role of apoptosis in the etiology of lymphopenia in patients with COVID-19. This multicentered, prospective, and case-control study was conducted with polymerase chain reaction (+) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients, and an age-gender-matched control group. Samples were taken at the time of diagnosis and analyzed via flow cytometry within 24 h. The participants' demographic data and initial laboratory tests were also recorded. In total, 33 patients with COVID-19 (mean age = 45.4 +/- 17.2) and 25 controls (mean age = 43.4 +/- 17.4) participated in the study. All patients were identified as having mild (16), moderate (5), or severe (12) disease severity. Both early and late apoptotic cells in B and T lymphocytes were increased in all patients with COVID-19 (p < .05). Early apoptotic (EA) B and T lymphocytes were also higher in severe cases compared to mild cases (p = .026). There was no significant difference between lymphopenia and apoptosis in patients with COVID-19. However, patients with lymphopenia (n = 14) and severe COVID-19 (p = .013) had increased EA T lymphocytes. This study's results show that B and T lymphocytes' apoptosis increases in patients with COVID-19. In addition, enhanced T lymphocyte apoptosis is associated with disease severity in lymphopenic patients with COVID-19.en_US
dc.description.sponsorshipScientific Research Project Fund of Selcuk University [20401092]en_US
dc.description.sponsorshipScientific Research Project Fund of Selcuk University, Grant/Award Number: 20401092en_US
dc.identifier.doi10.1002/jmv.26742
dc.identifier.endpage2874en_US
dc.identifier.issn0146-6615
dc.identifier.issn1096-9071
dc.identifier.issue5en_US
dc.identifier.pmid33331657en_US
dc.identifier.scopus2-s2.0-85101198780en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2867en_US
dc.identifier.urihttps://doi.org/10.1002/jmv.26742
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10587
dc.identifier.volume93en_US
dc.identifier.wosWOS:000620720000001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Medical Virologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectCovid-19en_US
dc.subjectDisease Severityen_US
dc.subjectLymphopeniaen_US
dc.titleApoptosis-induced T-cell lymphopenia is related to COVID-19 severityen_US
dc.typeArticleen_US

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