Serum total oxidant/anti-oxidant status, ischemia-modified albumin and oxidized-low density lipoprotein levels in patients with vitamin D deficiency

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dc.contributor.authorBaser, Husniye
dc.contributor.authorCan, Ummugulsum
dc.contributor.authorBaser, Salih
dc.contributor.authorHidayetoglu, Bahauddin Taha
dc.contributor.authorAslan, Uysaler
dc.contributor.authorBuyuktorun, Ilker
dc.contributor.authorYerlikaya, Fatma Humeyra
dc.date.accessioned2024-02-23T14:32:13Z
dc.date.available2024-02-23T14:32:13Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractObjective: Oxidative damage may be responsible for the pathogenesis and complications of many diseases. Vitamin D deficiency has been suggested as a potential mediator of various extra-skeletal pathologies. However, there are limited data on anti-oxidant properties of vitamin D. Materials and methods: Forty-one subjects with vitamin D deficiency and 30 healthy controls were enrolled into the study. The levels of total anti-oxidant status (TAS), total oxidant status (TOS), ischemia-modified albumin (IMA), oxidized-low density lipoprotein (ox-LDL), high-sensitivity C-reactive protein (hs-CRP) and fibrinogen were measured in both groups. The measurements were repeated in 17 patients after the replacement of vitamin D. Results: Serum IMA and TOS levels were significantly higher (p < 0.001 and p = 0.035, respectively), while TAS levels were significantly lower in patients, compared to controls (p < 0.001). Additionally, fibrinogen was significantly higher in patients than controls (p = 0.003), while ox-LDL and hs-CRP levels were similar between two groups. After the replacement of vitamin D, TAS level significantly increased (p = 0.037), and TOS and fibrinogen levels significantly decreased (p = 0.043 and p = 0.010, respectively). Vitamin D levels were negatively correlated with IMA and fibrinogen levels (r = -0.500, p < 0.001 and r = -0.391, p = 0.002, respectively), although positively correlated with TAS levels (r = 0.430, p < 0.001). No correlation was found between vitamin D levels, and the TOS, ox-LDL and hs-CRP levels. Conclusions: In this study, while serum IMA, TOS and fibrinogen levels were increased, TAS levels were seen to be decreased in patients with vitamin D deficiency. These results suggest that oxidative/anti-oxidative balance shifts in favours of oxidative status in vitamin D deficiency.en_US
dc.identifier.doi10.1590/2359-3997000000055
dc.identifier.endpage324en_US
dc.identifier.issn2359-3997
dc.identifier.issn2359-4292
dc.identifier.issue4en_US
dc.identifier.pmid26331319en_US
dc.identifier.scopus2-s2.0-84989237410en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage318en_US
dc.identifier.urihttps://doi.org/10.1590/2359-3997000000055
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15544
dc.identifier.volume59en_US
dc.identifier.wosWOS:000360956700007en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSbem-Soc Brasil Endocrinologia & Metabologiaen_US
dc.relation.ispartofArchives Of Endocrinology Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectVitamin Den_US
dc.subjectTotal Anti-Oxidant Statusen_US
dc.subjectTotal Oxidant Statusen_US
dc.subjectIschemia-Modified Albuminen_US
dc.subjectOxidized-Low Density Lipoproteinen_US
dc.titleSerum total oxidant/anti-oxidant status, ischemia-modified albumin and oxidized-low density lipoprotein levels in patients with vitamin D deficiencyen_US
dc.typeArticleen_US

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