Perineural invasion is a better prognostic factor than extranodal extension in head and neck cancer

Basit Öğe Kaydı
dc.contributor.authorEryilmaz, Melek Karakurt
dc.contributor.authorKorkmaz, Mustafa
dc.contributor.authorKaraagac, Mustafa
dc.contributor.authorArtac, Mehmet
dc.date.accessioned2024-02-23T14:31:11Z
dc.date.available2024-02-23T14:31:11Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractBackground: The prognostic value of perineural invasion (PNI) in head and neck squamous cell carcinoma (HNSCC) remains controversial. This study investigated the impact of PNI on prognosis in HNSCC. A total of 49 patients with HNSCC who underwent primary surgical treatment were selected for the study. Univariate analysis of the survival curve was performed using the Kaplan-Meier method. Multivariate analysis was carried out by Cox regression. Results: PNI was present in 17 of 49 (34.7%) patients. The median follow-up was 18.7 months. The median DFS and OS were 16.6 months and 41.9 months, respectively. Univariate analyses showed that PNI was associated with OS (p: 0.02), but not with DFS (p: 0.50). ENE was associated only with DFS in univariate analysis (p: 0.04), but not OS (yes vs. no; 24.1 vs. 44.6 months, p: 0.21), and in multivariate analysis, ENE lost its significance for DFS (p: 0.12). Also, PNI was the only significant independent adverse prognostic factor for OS in multivariate analysis (p: 0.02). The median OS for patients with and without PNI was 17.1 months and 92.1 months, respectively. Conclusion: PNI was an independent factor for poor prognosis in patients with HNSCC. The presence of PNI compared to ENE was associated with a greater risk of death in HNSCC. Therefore, it would be appropriate to consider adjuvant therapy in the presence of PNI alone without other adverse risk features.en_US
dc.identifier.doi10.1186/s43163-021-00189-4
dc.identifier.issn1012-5574
dc.identifier.issn2090-8539
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85131807866en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.1186/s43163-021-00189-4
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15068
dc.identifier.volume38en_US
dc.identifier.wosWOS:000746591000001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEgyptian Journal Of Otolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHead And Neck Canceren_US
dc.subjectPerineural Invasionen_US
dc.subjectExtranodal Extensionen_US
dc.subjectPrognosisen_US
dc.titlePerineural invasion is a better prognostic factor than extranodal extension in head and neck canceren_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu