Increased ischaemia-modified albumin is associated with inflammation in acute rheumatic fever

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dc.contributor.authorKaratas, Zehra
dc.contributor.authorBaysal, Tamer
dc.contributor.authorSap, Fatih
dc.contributor.authorAlp, Hayrullah
dc.contributor.authorMehmetoglu, Idris
dc.date.accessioned2024-02-23T14:16:33Z
dc.date.available2024-02-23T14:16:33Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractIntroduction: Ischaemia-modified albumin, a novel biochemical marker for tissue ischaemia, was found to be associated with oxidative stress. The purpose of this study was to assess the role of ischaemia-modified albumin in the diagnosis of acute rheumatic fever and also to evaluate the ischaemia-modified albumin levels in children with heart valve disease. Methods: The study groups, aged 5-18 years, consisted of 128 individuals - 40 with acute rheumatic fever, 35 with congenital heart valve disease, 33 with chronic rheumatic heart disease, and 20 healthy control subjects. Results: The ischaemia-modified albumin, erythrocyte sedimentation rate, and C-reactive protein levels of the acute rheumatic fever group were significantly higher than those in the chronic rheumatic heart disease, congenital heart valve disease, and control groups, separately (p < 0.001). The ischaemia-modified albumin levels in both carditis and isolated arthritis subgroups of children with acute rheumatic fever were significantly higher than in the control group (p < 0.001, p < 0.01, respectively). However, there was no statistically significant difference between the chorea subgroup and control subjects. In addition, significant correlations were observed between ischaemia-modified albumin and acute phase reactants of patients with acute rheumatic fever (p < 0.001 for both erythrocyte sedimentation rate and C-reactive protein). The ischaemia-modified albumin levels of chronic rheumatic heart disease, congenital heart valve disease, and control subjects were similar. Conclusions: The increased level of ischaemia-modified albumin in children with acute rheumatic fever seems to be associated with inflammation. However, further studies are needed to provide stronger evidence.en_US
dc.identifier.doi10.1017/S1047951113000516
dc.identifier.endpage436en_US
dc.identifier.issn1047-9511
dc.identifier.issn1467-1107
dc.identifier.issue3en_US
dc.identifier.pmid23659227en_US
dc.identifier.scopus2-s2.0-84899432544en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage430en_US
dc.identifier.urihttps://doi.org/10.1017/S1047951113000516
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12712
dc.identifier.volume24en_US
dc.identifier.wosWOS:000334883700007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofCardiology In The Youngen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Rheumatic Feveren_US
dc.subjectChildrenen_US
dc.subjectChronic Rheumatic Heart Diseaseen_US
dc.subjectIschaemia-Modified Albuminen_US
dc.subjectCongenital Heart Valve Diseaseen_US
dc.titleIncreased ischaemia-modified albumin is associated with inflammation in acute rheumatic feveren_US
dc.typeArticleen_US

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