Left ventricular myocardial deformation abnormalities in seizure-free children with epilepsy

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dc.contributor.authorCelik, Serkan Fazli
dc.contributor.authorBaratali, Emre
dc.contributor.authorGuven, Ahmet Sami
dc.contributor.authorTorun, Yasemin Altuner
dc.date.accessioned2024-02-23T14:16:15Z
dc.date.available2024-02-23T14:16:15Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractPurpose: Although there is a higher risk of structural cardiac disease in people with epilepsy, there is no detailed advanced analysis of cardiac functions in patients with epilepsy. This study aimed to determine early echo cardiographic findings of Left Ventricular (LV) dysfunction using cardiac strain technique in seizure-free children with epilepsy. Method: The study investigated 60 children with epilepsy who had no seizures in the preceding 6 months, without any known cardiovascular disease and treated with one antiepileptic drug and 60 healthy subjects who underwent clinical evaluation including electrocardiography (ECG), standard echocardiography, tissue Doppler imaging (TDI) and two-dimensional Speckle Tracking Echocardiography (2DSTE). Results: Despite the normal M-mode values, global longitudinal strain of the epilepsy of the control group was as follows: -16.86 +/- 3.71,-18.95 +/- 3.75, respectively (p = 0.001); global strain rates were determined as follows: -0.99 +/- 0.23,-1.14 +/- 0.31, respectively (p = 0003). The patients also had increased A-wave velocity, and decreased E/A ratio (p < 0.01). TDI results showed diastolic dysfunction as mirrored by significantly increased isovolemic relaxation time (IVRT), Early mitral inflow (E)/ Early diastolic velocity (E'), and Tei index (p < 0.01). There was no significant difference in LV torsion, Peak LV twist, and ECG parameters between the patients and the controls. Conclusions: In seizure-free patients, cardiac systolic and diastolic functions were impaired when compared to healthy children. There was no difference in the patient group to explain the decline in cardiac functions and there may be unknown different factors besides the known risk factors.en_US
dc.identifier.doi10.1016/j.seizure.2018.08.017
dc.identifier.endpage157en_US
dc.identifier.issn1059-1311
dc.identifier.issn1532-2688
dc.identifier.pmid30170299en_US
dc.identifier.scopus2-s2.0-85052482649en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage153en_US
dc.identifier.urihttps://doi.org/10.1016/j.seizure.2018.08.017
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12587
dc.identifier.volume61en_US
dc.identifier.wosWOS:000447477500027en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co Ltden_US
dc.relation.ispartofSeizure-European Journal Of Epilepsyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEpilepsyen_US
dc.subjectEchocardiographyen_US
dc.subjectStrainen_US
dc.subjectChildrenen_US
dc.subjectVentricular Dysfunctionen_US
dc.titleLeft ventricular myocardial deformation abnormalities in seizure-free children with epilepsyen_US
dc.typeArticleen_US

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