Quantitative assessment of the effect of SARS-CoV-2 on the corneal sub-basal nerve plexus of post-COVID-19 patients using in vivo confocal microscopy

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dc.contributor.authorMirza, Enver
dc.contributor.authorBelviranli, Selman
dc.contributor.authorGundogan, Ali Osman
dc.contributor.authorAdam, Mehmet
dc.contributor.authorOltulu, Refik
dc.date.accessioned2024-02-23T14:16:44Z
dc.date.available2024-02-23T14:16:44Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractObjectives To investigate whether SARS-CoV-2 causes morphological changes in the corneal sub-basal nerve plexus (CSNP) of post-COVID-19 patients using in vivo confocal microscopy (IVCM). Methods A total of 70 participants were included in the study and were divided into three groups. Post-COVID-19 patients with neurological manifestations were considered Group 1 (n = 24), and post-COVID-19 patients without neurological manifestations were considered Group 2 (n = 24). Healthy control participants were considered Group 3 (n = 22). The parameters of the CSNP, including nerve fibre density (NFD), nerve branch density (NBD), and nerve fibre length (NFL), were investigated in all participants using IVCM. Additionally, corneal sensitivity was tested by corneal esthesiometry. Results The mean NFD, NBD, and NFL values of Group 1 (16.12 +/- 4.84 fibre/mm(2), 27.97 +/- 9.62 branch/mm(2), and 11.60 +/- 2.89 mm/mm(2)) were significantly lower than those of Group 2 (19.55 +/- 3.01 fibre/mm(2), 40.44 +/- 7.16 branch/mm(2), and 15.92 +/- 2.08 mm/mm(2)) and Group 3 (25.24 +/- 3.75 fibre/mm(2), 44.61 +/- 11.80 branch/mm(2), and 17.76 +/- 3.32 mm/mm(2)) (p < 0.05 for all). Except the mean NFD value (p < 0.001), there were no significant differences in terms of the mean NBD and NFL values between Group 2 and Group 3 (p = 0.445, p = 0.085). The value of the mean corneal sensitivity was significantly higher in Group 3 (59.09 +/- 1.97 mm) compared to Group 1 (55.21 +/- 1.02 mm) and Group 2 (55.28 +/- 1.18 mm) (p < 0.001, p < 0.001) but there was no significant difference between Group 1 and Group 2 (p = 1.000). Conclusion In post-COVID-19 patients, the mean parameters of CSNP were lower than in the control group. These differences were more pronounced in patients who had neurological manifestations of COVID-19.en_US
dc.identifier.doi10.1038/s41433-022-02018-1
dc.identifier.endpage664en_US
dc.identifier.issn0950-222X
dc.identifier.issn1476-5454
dc.identifier.issue4en_US
dc.identifier.pmid35322211en_US
dc.identifier.scopus2-s2.0-85126870870en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage660en_US
dc.identifier.urihttps://doi.org/10.1038/s41433-022-02018-1
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12759
dc.identifier.volume37en_US
dc.identifier.wosWOS:000772547100002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofEyeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleQuantitative assessment of the effect of SARS-CoV-2 on the corneal sub-basal nerve plexus of post-COVID-19 patients using in vivo confocal microscopyen_US
dc.typeArticleen_US

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