The Evaluation of Dietary Antioxidant Capacity, Dietary Inflammatory Index and Serum Biomarkers in Breast Cancer: A Prospective Study

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dc.contributor.authorAlkan, Senay Burcin
dc.contributor.authorArtac, Mehmet
dc.contributor.authorAksoy, Faruk
dc.contributor.authorBelviranli, Mehmet Metin
dc.contributor.authorGurbilek, Mehmet
dc.contributor.authorCizmecioglu, Hilal Akay
dc.contributor.authorRakicioglu, Neslisah
dc.date.accessioned2024-02-23T14:17:15Z
dc.date.available2024-02-23T14:17:15Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractDietary antioxidant capacity (dTAC) and dietary inflammatory index (DII) are commonly used to assess nutrition. This prospective study examined dTAC, DII, and serum biomarkers in women with breast cancer (BC). Patients were followed-up before surgery (T-1), before chemotherapy (T-2), at 6(th) (T-3) and 12(th) months of chemotherapy (T-4). Serum tumor necrosis factor alpha, interleukin 1 & beta;, interleukin 6, protein carbonyl, malondialdehyde, total antioxidant capacity (TAC), and total oxidant status levels were analyzed. Dietary antioxidant intake, dTAC, and DII were determined using a three-day dietary record. dTAC was calculated using vitamin C equivalent (VCE), oxygen radical absorption capacity (ORAC), trolox equivalent antioxidant capacity (TEAC), total radical-trapping antioxidant parameter (TRAP), and ferrous ion reducing antioxidant potential (FRAP). This study included 32 women with BC and 32 controls (CG). ORAC, TEAC, TRAP, and FRAP were significantly lower in BC than in CG. During follow-up, only ORAC increased significantly at T-2 compared to T-1. A weak positive correlation was found between dTAC (VCE) and serum TAC levels at T-2 (rho = 0.371, p = 0.036). The relationship between diet and serum biomarkers was not significant. Multicenter prospective studies on different age groups are needed to understand the association between diet and serum biomarkers levels in patients with BC.en_US
dc.description.sponsorshipTurkish Society of Medical Oncology [TTOD-2019-47]en_US
dc.description.sponsorshipAcknowledgmentsWe would like to thank women that have participated in this research for their meaningful contributions and Turkish Society of Medical Oncology for support the research. We also would like to thank to Dr. Ahmad Al-Khattat for his valuable support in writing the manuscript. The relationship between dietary and serum advanced glycation end-products and serum inflammation and oxidation biomarkers of the participants were evaluated in a previously published article (See ref. (16).en_US
dc.identifier.doi10.1080/01635581.2023.2227404
dc.identifier.endpage1637en_US
dc.identifier.issn0163-5581
dc.identifier.issn1532-7914
dc.identifier.issue8en_US
dc.identifier.pmid37353899en_US
dc.identifier.scopus2-s2.0-85162914812en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1625en_US
dc.identifier.urihttps://doi.org/10.1080/01635581.2023.2227404
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13014
dc.identifier.volume75en_US
dc.identifier.wosWOS:001012949800001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherRoutledge Journals, Taylor & Francis Ltden_US
dc.relation.ispartofNutrition And Cancer-An International Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleThe Evaluation of Dietary Antioxidant Capacity, Dietary Inflammatory Index and Serum Biomarkers in Breast Cancer: A Prospective Studyen_US
dc.typeArticleen_US

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