Prostate incidentaloma on 18F-fluorodeoxyglucose positron emission tomography: Diagnostic value of volumetric positron emission tomography parameters

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dc.contributor.authorSahin, Ozlem
dc.contributor.authorKaya, Bugra
dc.contributor.authorAydin, Zeynep
dc.contributor.authorSen, Ahmet Eren
dc.contributor.authorIyisoy, Mehmet Sinan
dc.contributor.authorAydin, Arif
dc.date.accessioned2024-02-23T14:16:50Z
dc.date.available2024-02-23T14:16:50Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractObjective To evaluate whether volumetric PET parameters such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG) contributed to maximum standardized uptake value (SUVmax) in predicting prostate carcinoma in the prostate incidentalomas (PI) in 18F-FDG PET/CT. Materials and methods This retrospective study comprised 107 patients with PI of 4723 male patients who had undergone 18F-FDG PET/CT. SUVmax and volumetric PET parameters of PIs were assessed. MTV and TLG were acquired with each SUV threshold as 2.5, 3.0, 3.5, 4.0, 4.5, and 5.0. Results The PI incidence was 2.3 %, and the malignancy ratio of PI was 15.9 %. According to further analysis results, 17 patients were in the malignant group, and 46 patients were in the benign group. Malignant PIs had higher SUVmax (10.6 vs. 6.4 and p < 0.01), MTV (all p < 0.01) and TLG (all p < 0.01) than benign incidentalomas. All volumetric PET parameters had higher area under the curve (AUC) than SUVmax. SUVmax AUC was 0.835 [95 % confidence interval (CI): 0.728-0.942]. MTV 2.5 and TLG 2.5 had the highest performance for predicting malignant PI. MTV2.5 AUC was 0.871 (95 % CI: 0.775-0.968), and TLG2.5 AUC was 0.882 (95 % CI: 0.797-0.967). Using TLG 2.5 greater than 29.8 as the cut-off point, the sensitivity and specificity for malignancy prediction were 94.1 % and 82.6 %, respectively. Conclusion In this study, in which the effectiveness of volumetric parameters in the diagnosis of PI was evaluated for the first time, it was shown that they could potentially have clinical value along with SUVmax.en_US
dc.identifier.doi10.1055/a-1525-7607
dc.identifier.endpage402en_US
dc.identifier.issn0029-5566
dc.identifier.issn2567-6407
dc.identifier.issue6en_US
dc.identifier.pmid34243190en_US
dc.identifier.scopus2-s2.0-85110395634en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage394en_US
dc.identifier.urihttps://doi.org/10.1055/a-1525-7607
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12826
dc.identifier.volume60en_US
dc.identifier.wosWOS:000673009700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofNuklearmedizin-Nuclear Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectProstate Incidentalomaen_US
dc.subjectVolumetric Pet Parametersen_US
dc.subjectMtven_US
dc.subjectTlgen_US
dc.subjectSuven_US
dc.titleProstate incidentaloma on 18F-fluorodeoxyglucose positron emission tomography: Diagnostic value of volumetric positron emission tomography parametersen_US
dc.typeArticleen_US

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