Evaluation of subclinical cardiovascular risk in drug-naive pediatric patients with anxiety disorders

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dc.contributor.authorAkinci, Mehmet Akif
dc.contributor.authorUzun, Necati
dc.contributor.authorAlp, Hayrullah
dc.date.accessioned2024-02-23T14:26:55Z
dc.date.available2024-02-23T14:26:55Z
dc.date.issued2024
dc.departmentNEÜen_US
dc.description.abstractObjective This study aims to evaluate subclinical atherosclerosis in drug-naive children with anxiety disorders using non-invasive measures and to investigate the clinical features associated with subclinical atherosclerosis. Method This study included 37 drug-naive children and adolescents with anxiety disorders and 37 healthy controls. The Children's Depression Inventory (CDI) and the State-Trait Anxiety Inventory (STAI-T and STAI-S) were used to assess children's depression and anxiety levels. Carotid artery intima-media (cIMT), epicardial adipose tissue (EAT), and periaortic adipose tissue (PAT) thicknesses, which are indicators of subclinical atherosclerosis, were obtained by echocardiographic measurements. Results Multivariate analysis of covariance (MANCOVA) revealed a significant main effect for cIMT, EAT thickness, and PAT thickness in both groups, independent of confounding factors such as age, sex, body mass index, mean blood pressure, and family income (Pillai's Trace V = .76, F (1, 72) = 35.60, P < .001, & eta;p(2) = .76). Analysis of covariance (ANCOVA) showed that cIMT, EAT thickness, and PAT thickness values were significantly higher in the anxiety disorder group than in the control group (P < .001). In partial correlation analysis, a positive correlation was observed between STAI-T and cIMT, and EAT thickness. In linear regression analyses, age and STAI-T were identified as correlates of cIMT and EAT thickness levels. Conclusions These results suggest that subclinical cardiovascular risk is significantly increased in children and adolescents with anxiety disorders.en_US
dc.identifier.doi10.1177/00912174231196342
dc.identifier.endpage166en_US
dc.identifier.issn0091-2174
dc.identifier.issn1541-3527
dc.identifier.issue2en_US
dc.identifier.pmid37578806en_US
dc.identifier.scopus2-s2.0-85168454432en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage153en_US
dc.identifier.urihttps://doi.org/10.1177/00912174231196342
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14370
dc.identifier.volume59en_US
dc.identifier.wosWOS:001047871900001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofInternational Journal Of Psychiatry In Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnxiety Disordersen_US
dc.subjectCardiovascular Risken_US
dc.subjectCarotid Intima-Media Thicknessen_US
dc.subjectEpicardial Adipose Tissue Thicknessen_US
dc.subjectPeriaortic Adipose Tissue Thicknessen_US
dc.subjectSubclinical Atherosclerosisen_US
dc.titleEvaluation of subclinical cardiovascular risk in drug-naive pediatric patients with anxiety disordersen_US
dc.typeArticleen_US

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