Favorable electrocardiographic changes after substantial weight loss in patients with morbid obesity Results of a prospective study

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dc.contributor.authorGul, Murat
dc.contributor.authorInci, Sinan
dc.contributor.authorOzkan, Namik
dc.contributor.authorAlsancak, Yakup
dc.date.accessioned2024-02-23T13:43:28Z
dc.date.available2024-02-23T13:43:28Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractBackground Obese patients have an increased risk of arrhythmias and sudden death, even in the absence of structural heart disease and cardiac dysfunction. This study aimed to determine whether weight loss by bariatric surgery has an effect on arrhythmia-related electrocardiographic (ECG) variables in morbidly obese patients. Methods In this prospective study, the data of 48 patients were analyzed. All ECG variables that have the potential to predict ventricular arrhythmia were evaluated before surgery, and were compared with the 1-month and 6-month follow-up results. Results The mean body mass index was 45.74 +/- 5.60 kg/m(2) before surgery. There was a statistically significant decline in body mass index in the first and sixth month after surgery (39.26 +/- 5.00 kg/m(2) and 31.71 +/- 4.49 kg/m(2), respectively; p < 0.001). Furthermore, notable reduction was found in terms of heart rate measurements-QTc-d, JTc, JTc-d, Tp-e, TP-e/QT, TP-e/QTc-in the first month and sixth month compared with baseline (p < 0.001 for all comparisons). Several ECG variables, such as heart rate (r = 0.369, p = 0.001), QTc-d (r = 0.449, p = 0.001), JTc-d (r = 0.324, p = 0.002), Tp-e (r = 0.592, p = 0.001), Tp-e/QTc (r = 0.543, p = 0.001), Tp-e/JTc (r = 0.515, p = 0.001), exhibited a positive and significant correlation with weigh loss. Moreover, a negative and weakly significant correlation was found between the index of cardiac electrophysiological balance (r = -0.239, p = 0.004) and body mass index. Conclusion Substantial weight loss following laparoscopic sleeve gastrectomy in obese patients is accompanied by a significant improvement in ventricular repolarization. Therefore, this effect may lead to a decrease in the incidence of lethal ventricular arrhythmia and sudden cardiac death.en_US
dc.identifier.doi10.1007/s00059-020-05019-6
dc.identifier.endpage574en_US
dc.identifier.issn0340-9937
dc.identifier.issn1615-6692
dc.identifier.issue6en_US
dc.identifier.pmid33502574en_US
dc.identifier.scopus2-s2.0-85099814962en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage567en_US
dc.identifier.urihttps://doi.org/10.1007/s00059-020-05019-6
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10823
dc.identifier.volume46en_US
dc.identifier.wosWOS:000612250000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherUrban & Vogelen_US
dc.relation.ispartofHerzen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArrhythmiasen_US
dc.subjectEcgen_US
dc.subjectBariatric Surgeryen_US
dc.subjectObesityen_US
dc.subjectVentricular Repolarizationen_US
dc.titleFavorable electrocardiographic changes after substantial weight loss in patients with morbid obesity Results of a prospective studyen_US
dc.typeArticleen_US

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