Antimicrobial cerium ion-chitosan crosslinked alginate biopolymer films: A novel and potential wound dressing

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dc.contributor.authorKaygusuz, Hakan
dc.contributor.authorTorlak, Emrah
dc.contributor.authorAkm-Evingur, Gulsen
dc.contributor.authorOzen, Ilhan
dc.contributor.authorvon Klitzing, Regine
dc.contributor.authorErim, F. Bedia
dc.date.accessioned2024-02-23T14:03:08Z
dc.date.available2024-02-23T14:03:08Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractWound dressings require good antiseptic properties, mechanical strength and, more trustably, natural material ingredients. Antimicrobial properties of cerium ions and chitosan are known and alginate based wound dressings are commercially available. In this study, the advantages of these materials were combined and alginate films were crosslinked with cerium(III) solution and chitosan added cerium(III) solution. Films were characterized by Fourier transform infrared spectroscopy (FTIR), light transmittance, scanning electron microscopy (SEM), swelling expefiments, water vapor transmittance tests, and mechanical stretching tests. The antibacterial and physical properties of the films were compared with those of conventional calcium alginate films. Both cerium ion crosslinked and cerium ion-chitosan crosslinked alginate films gained antibacterial activity against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria. Cerium alginate-chitosan films showed high resistance to being deformed elastically. Results show that cerium alginate-chitosan films can be flexible, ultraviolet protecting, and antibacterial wound dressings. (C) 2017 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipResearch Foundation of Istanbul Technical University; Scientific and Technical Research Council of Turkey (TUBITAK) [BIDEB 2214/B]en_US
dc.description.sponsorshipWe thank the Research Foundation of Istanbul Technical University for financial support. H. Kaygusuz acknowledges Scientific and Technical Research Council of Turkey (TUBITAK) BIDEB 2214/B scholarship program.en_US
dc.identifier.doi10.1016/j.ijbiomac.2017.07.144
dc.identifier.endpage1165en_US
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid28751050en_US
dc.identifier.scopus2-s2.0-85026366834en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1161en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2017.07.144
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11975
dc.identifier.volume105en_US
dc.identifier.wosWOS:000414882900130en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofInternational Journal Of Biological Macromoleculesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlginateen_US
dc.subjectChitosanen_US
dc.subjectWound Dressingen_US
dc.titleAntimicrobial cerium ion-chitosan crosslinked alginate biopolymer films: A novel and potential wound dressingen_US
dc.typeArticleen_US

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