The Role of Adenovirus in Hepatitis of Unknown Etiology Among Children in Turkey, July 2022 to January 2023

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dc.contributor.authorDemirbuga, Asuman
dc.contributor.authorHancerli Torun, Selda
dc.contributor.authorMetin-Akcan, Oezge
dc.contributor.authorYucel, Aylin
dc.contributor.authorYahsi, Aysun
dc.contributor.authorBayhan, Gulsum Iclal
dc.contributor.authorEmre, Irmak
dc.date.accessioned2024-02-23T14:21:10Z
dc.date.available2024-02-23T14:21:10Z
dc.date.issued2024
dc.departmentNEÜen_US
dc.description.abstractBackground:In the first half of 2022, the increase in cases of severe acute hepatitis in children with no epidemiological link and unknown cause has aroused concern worldwide. In this study, we aimed to determine the frequency of adenovirus in children with hepatitis of unknown origin in Turkey.Methods:In this study, which was conducted with the participation of 16 centers from Turkey, between July 2022 and January 2023, 36 pediatric patients under the age of 18 who met the definition of acute hepatitis were included.Results:Twenty (55,6%) of patients were female and 16 (44,4%) were male, with a mean age of 41.55 +/- 39.22 (3-192) months. The most common symptoms were fever (66.7%), weakness (66.7%), loss of appetite (66.7%), fatigue (61.1%), vomiting (61.1%), and diarrhea (47.2%). Six (16 %) children had acute hepatic failure. Eight of the 15 children (46%) had respiratory viral infections (rhinovirus/enterovirus, n = 4; rhinovirus + parainfluenza, n = 1; parainfluenza, n = 1, SARS-CoV-2 n = 2). Adenovirus was detected in 16 (44%) patients. Adenovirus and coinfections were detected in 7 patients. History of diarrhea and fatigue in the last month was significantly higher in the adenovirus group (P = 0.023 and 0.018). One child who had both adenovirus and rhinovirus infection required liver transplantation; all others recovered with supportive care.Conclusion:There were no deaths in our series; however, the number of cases, etiology, and severity of the clinical course may have differed between countries owing to differences in case definitions, laboratory facilities, or regional genetic differences.en_US
dc.identifier.doi10.1097/INF.0000000000004094
dc.identifier.endpage6en_US
dc.identifier.issn0891-3668
dc.identifier.issn1532-0987
dc.identifier.issue1en_US
dc.identifier.pmid37725812en_US
dc.identifier.scopus2-s2.0-85180005445en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1097/INF.0000000000004094
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13467
dc.identifier.volume43en_US
dc.identifier.wosWOS:001125469400002en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofPediatric Infectious Disease Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdenovirusen_US
dc.subjectChildrenen_US
dc.subjectHepatitisen_US
dc.subjectOutbreaken_US
dc.titleThe Role of Adenovirus in Hepatitis of Unknown Etiology Among Children in Turkey, July 2022 to January 2023en_US
dc.typeArticleen_US

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