The role of Prominin-1 , marker in adenomatous colorectal polyps

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dc.contributor.authorSafiyeva, Aynur
dc.contributor.authorBayramov, Nuru
dc.contributor.authorAvunduk, Mustafa Cihat
dc.date.accessioned2024-02-23T14:41:51Z
dc.date.available2024-02-23T14:41:51Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractIntroduction: Adenomatous polyps are pivotal to the development of colorectal cancer. The risk of colorectal carcinogenesis can be reduced through polypectomy and close surveillance of the disease. Early-stage polyps can be detected and removed endoscopically, therefore, reducing the incidence of carcinoma. The identification of CSC in colon polyps allows for assessment of their potential malignancy. Therefore, it is very relevant to study the prognostic significance of the prevalence of stem cells in colorectal polyps in early detection and prevention of cancer. Method: Previously pathologically evaluated adenomatous tumors (60M, 40F) at Azerbaijan Medical University were reevaluated in Meram Medical Faculty Pathology Department. Hematoxylin-Eosin-stained slides were examined and cases with and without dysplasia were determined. New sections were taken from paraffin blocs. Promin in-1 staining was performed immunohistochemically on these sections. Stained slides were examined by an image analysis system. Prominin-1-positive cells were automatically counted with the same image analysis system. The cases that developed malignancy after polypectomy were determined. The relationship between CD133 expression of dysplasia and malignancy was statistically analyzed. Results: Statistically significant prominin-1 expression was detected in cases with dysplasia and malignancy. Conclusion: The investigation of prominin-1 expression in colorectal polyps may be important to determine malignancy development.en_US
dc.identifier.doi10.5604/01.3001.0015.4874
dc.identifier.endpage25en_US
dc.identifier.issn0032-373X
dc.identifier.issn2299-2847
dc.identifier.issue2en_US
dc.identifier.pmid35485315en_US
dc.identifier.scopus2-s2.0-85129779923en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage19en_US
dc.identifier.urihttps://doi.org/10.5604/01.3001.0015.4874
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17035
dc.identifier.volume94en_US
dc.identifier.wosWOS:000819927600004en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIndex Copernicus Inten_US
dc.relation.ispartofPolish Journal Of Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdenomatous Polypsen_US
dc.subjectColorectal Polypsen_US
dc.subjectDysplasiaen_US
dc.subjectMalignancyen_US
dc.subjectProminin-1en_US
dc.titleThe role of Prominin-1 , marker in adenomatous colorectal polypsen_US
dc.typeArticleen_US

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