Cilostazol-induced relaxation of calf cardiac vein and coronary artery during cooling

Basit Öğe Kaydı
dc.contributor.authorNurullahoglu-Atalik, K. E.
dc.contributor.authorNurullahoglu, Z. U.
dc.contributor.authorKilic, M.
dc.contributor.authorAribas, A.
dc.date.accessioned2024-02-23T14:37:58Z
dc.date.available2024-02-23T14:37:58Z
dc.date.issued2013
dc.departmentNEÜen_US
dc.description.abstractObjective: At present very little is known about the role of endothelial nitric oxide (NO) in the effects of temperature on vascular reactivity. The aim of the present study is to evaluate the influence of cooling (to 28 degrees C) on the vasodilatation induced by cilostazol(10(-9)-3x10(-4)M) on carbachol (10(-6))-precontracted calf cardiac vein and coronary artery and the role of NO in these effects. Materials and methods: Ring preparations of great cardiac vein and the anterior interventricular branch of left coronary artery were used. Results: Cilostazol produced concentration-dependent relaxation of calf cardiac vein and coronary artery rings precontracted with carbachol. During cooling, the pIC(50) values, but not the maximal responses to cilostazol were significantly lower than at 37 degrees C in both preparations. Cooling to 28 degrees C in the presence of N-G-nitro-L-arginine methyl ester (L-NAME, 10(-4) M) did not modify the effect of temperature both in cardiac vein and coronary artery. These results demonstrate for the first time that cooling-induced changes of cilostazol in calf cardiac vein and coronary artery are independent of NO (Tab. 2, Fig. 3, Ref. 32). Full Text in PDF www.elis.sk.en_US
dc.identifier.doi10.4149/BLL_2013_117
dc.identifier.endpage560en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue10en_US
dc.identifier.pmid24156677en_US
dc.identifier.scopus2-s2.0-84886736605en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage556en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2013_117
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16309
dc.identifier.volume114en_US
dc.identifier.wosWOS:000331063100002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCardiac Veinen_US
dc.subjectCilostazolen_US
dc.subjectCoolingen_US
dc.subjectCoronary Arteryen_US
dc.subjectNitric Oxideen_US
dc.titleCilostazol-induced relaxation of calf cardiac vein and coronary artery during coolingen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu