The role of neutrophil lymphocyte ratio to leverage the differential diagnosis of familial Mediterranean fever attack and acute appendicitis

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dc.contributor.authorKucuk, Adem
dc.contributor.authorErol, Mehmet Fatih
dc.contributor.authorSenel, Soner
dc.contributor.authorEroler, Emir
dc.contributor.authorYumun, Havvanur Alparslan
dc.contributor.authorUslu, Ali Ugur
dc.contributor.authorErol, Asiye Mukaddes
dc.date.accessioned2024-02-23T14:35:27Z
dc.date.available2024-02-23T14:35:27Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractBackground/Aims: Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterized by attacks of fever and diffuse abdominal pain. The primary concern with this presentation is to distinguish it from acute appendicitis promptly. Thus, we aimed to evaluate the role of neutrophil lymphocyte ratio (NLR) to leverage the differential diagnosis of acute FMF attack with histologically proven appendicitis. Methods: Twenty-three patients with histologically confirmed acute appendicitis and 88 patients with acute attack of FMF were included in the study. NLR, C-reactive protein and other hematologic parameters were compared between the groups. Results: Neutrophil to lymphocyte ratio was significantly higher in patients with acute appendicitis compared to the FMF attack group (8.24 +/- 6.31 vs. 4.16 +/- 2.44, p = 0.007). The performance of NLR in diagnosing acute appendicitis with receiver operating characteristic analysis with a cut-off value of 4.03 were; 78% sensitivity, 62% specificity, and area under the curve 0.760 (95% confidence interval, 0.655 to 0.8655; p < 0.001). Conclusions: This study showed that NLR, the simple and readily available inflammatory marker may have a useful role in distinguishing acute FMF attack from acute appendicitis.en_US
dc.identifier.doi10.3904/kjim.2015.039
dc.identifier.endpage391en_US
dc.identifier.issn1226-3303
dc.identifier.issn2005-6648
dc.identifier.issue2en_US
dc.identifier.pmid26864298en_US
dc.identifier.scopus2-s2.0-84960155254en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage386en_US
dc.identifier.urihttps://doi.org/10.3904/kjim.2015.039
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16034
dc.identifier.volume31en_US
dc.identifier.wosWOS:000372174600020en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKorean Assoc Internal Medicineen_US
dc.relation.ispartofKorean Journal Of Internal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNeutrophil-To-Lymphocyte Ratioen_US
dc.subjectFamilial Mediterranean Fever Attacken_US
dc.subjectAcute Appendicitisen_US
dc.subjectAbdominal Painen_US
dc.subjectInflammationen_US
dc.titleThe role of neutrophil lymphocyte ratio to leverage the differential diagnosis of familial Mediterranean fever attack and acute appendicitisen_US
dc.typeArticleen_US

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