Obstructive Sleep Apnea Syndrome May Be a Risk Factor for the Development of Osteoporosis in Men at an Early Age?

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dc.contributor.authorAslan, Saadet Han
dc.contributor.authorYosunkaya, Sebnem
dc.contributor.authorKiyici, Aysel
dc.contributor.authorSari, Oktay
dc.date.accessioned2024-02-23T14:41:15Z
dc.date.available2024-02-23T14:41:15Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractObjective: Chronic intermittent hypoxia due to respiratory events occurring during sleep and sleep fragmentation due to arousals in obstructive sleep apnea syndrome (OSAS) may affect bone mineral density (BMD) directly or may be by causing a change in BMD through effects on hormones. We aimed to investigate whether any BMD change or any change in the level of hormones [growth hormone (GH), insulinlike growth factor-1 (IGF-1), free testosterone, total testosterone, and sex hormone-binding globulin (SHBG)], which may be related to BMD, occurs in middle-aged male patients with OSAS and compare the same with normal individuals. Material and Methods: Blood samples were collected from the participants in the morning (07.00-08.00 AM) after applying polysornnography for diagnosis. CH, IGF-1, total testosterone, and SHBG levels were measured using the enzyme-linked imrnunosorbent assay method, whereas the free testosterone level was measured using the radioimmunoassay method. BMD was measured at the femoral neck and lumbar vertebra using the Dual energy X-ray absorptiornetry (DEXA) method. Results: Between the two groups of hormones levels and T-score values statistically significant difference was not obtained. There was a statistically significant positive relationship between age and T-score femur (p<0.001) and T-score vertebra (p=0.017) and between rapid eye movement sleep time and T-score femur (p=0.032) in the OSAS group. Although patients who have BMD <-2.5 in the OSAS group (5/24) was detected to be higher than the control group (0/22), the difference was not statistically significant (p=0.05). Conclusion: In this study, we demonstrated that OSAS may not be a risk factor in the development of osteoporosis in middle-aged male patients. In addition, there was no direct relation between BMD and chronic intermittent hypoxia, apnea hypopnea index, or excessive sleepiness. Furthermore, we could not obtain any distinct relationship between OSAS and hormonal parameters that affects BMD.en_US
dc.description.sponsorshipSelcuk University Scientific Research [09102031]en_US
dc.description.sponsorshipThis study was supported by the 09102031 project number Selcuk University Scientific Research Projects Coordinator.en_US
dc.identifier.doi10.5152/tftrd.2015.59913
dc.identifier.endpage222en_US
dc.identifier.issn1302-0234
dc.identifier.issn1308-6316
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84943258942en_US
dc.identifier.startpage216en_US
dc.identifier.urihttps://doi.org/10.5152/tftrd.2015.59913
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16759
dc.identifier.volume61en_US
dc.identifier.wosWOS:000366590900005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherAvesen_US
dc.relation.ispartofTurkiye Fiziksel Tip Ve Rehabilitasyon Dergisi-Turkish Journal Of Physical Medicine And Rehabilitationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectObstructive Sleep Apnea Syndromeen_US
dc.subjectOsteoporosisen_US
dc.subjectChen_US
dc.subjectIgf-1en_US
dc.subjectTestosteroneen_US
dc.subjectShbgen_US
dc.titleObstructive Sleep Apnea Syndrome May Be a Risk Factor for the Development of Osteoporosis in Men at an Early Age?en_US
dc.typeArticleen_US

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