Synthesis of biologically active copper oxide nanoparticles as promising novel antibacterial-antibiofilm agents

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dc.contributor.authorErci, Fatih
dc.contributor.authorCakir-Koc, Rabia
dc.contributor.authorYontem, Mustafa
dc.contributor.authorTorlak, Emrah
dc.date.accessioned2024-02-23T14:20:30Z
dc.date.available2024-02-23T14:20:30Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractIn this study, we aimed to synthesize copper oxide nanoparticles (CuONPs) mediated by plant extract in an environmentally friendly way and to reveal their potential biological activities. Here we synthesized CuONPs by using different concentrations of aqueous leaf extract of Thymbra spicata at 80 degrees C to obtain Ts1CuONPs and Ts2CuONPs. Biosynthesized nanoparticles were characterized by using UV-Vis, AFM, FTIR, SEM-EDS, TEM, DLS and zeta potential analysis. The antibacterial activity of the nanoparticles was determined by calculation of the inhibition zone and minimum inhibitory concentration against selected bacterial strains. Moreover, the antioxidant activity of the as-synthesized nanoparticles was evaluated based on DPPH radical scavenging activity. The results indicate that the as-synthesized NPs have an average size of 26.8 and 21 nm for Ts1CuONPs and Ts2CuONPs, respectively. The formed CuONPs have more antibacterial action on gram-positive bacteria compared to gram-negative bacteria. In addition, CuONPs demonstrated good inhibition activity against biofilm formation of Staphylococcus aureus (S. aureus). Furthermore, the results showed that the smaller size of the CuONPs caused the higher cytotoxicity on L929 mouse fibroblast cells. The as-synthesized CuONPs exhibit antibacterial and antibiofilm potential against S. aureus, indicating that they may be attractive candidates to use in future therapeutic applications.en_US
dc.identifier.doi10.1080/10826068.2019.1711393
dc.identifier.endpage548en_US
dc.identifier.issn1082-6068
dc.identifier.issn1532-2297
dc.identifier.issue6en_US
dc.identifier.pmid31922463en_US
dc.identifier.scopus2-s2.0-85078636406en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage538en_US
dc.identifier.urihttps://doi.org/10.1080/10826068.2019.1711393
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13182
dc.identifier.volume50en_US
dc.identifier.wosWOS:000506511100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofPreparative Biochemistry & Biotechnologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibacterialen_US
dc.subjectAntibiofilmen_US
dc.subjectBiosynthesisen_US
dc.subjectCopper Oxide Nanoparticlesen_US
dc.subjectCytotoxicityen_US
dc.titleSynthesis of biologically active copper oxide nanoparticles as promising novel antibacterial-antibiofilm agentsen_US
dc.typeArticleen_US

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