Effect of Moringa oleifera on serum YKL-40 level: In vivo rat periodontitis model

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dc.contributor.authorKocabas, Rahim
dc.contributor.authorYarkac, Fatma Ucan
dc.contributor.authorKarabulut, Ercan
dc.contributor.authorKeles, Mert
dc.date.accessioned2024-02-23T14:29:49Z
dc.date.available2024-02-23T14:29:49Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractPeriodontitis is a chronic inflammatory disease that destroys the bones and soft tissues that support the tooth as a result of inflammatory reactions. YKL-40 is an inflammatory marker associated with inflammation and is also associated with periodontal diseases. Moringa oleifera (MO) is a plant rich in high nutritional values, minerals, vitamins, and other essential phytochemicals. The aim of this study was to investigate the effect of MO administration on serum YKL-40 levels in an experimental periodontitis model. In the study, a total number of 24 female Wistar albino rats, which were 4-5 months old with a body weight of 275 +/- 25 g, were used. Animals were divided into three groups. 1st group: Control (n = 8), 2nd group: periodontitis group (PG) (n = 8), 3rd group: Periodontitis group (PG + MO) with an additional 200 mg/kg/4 weeks MO (n = 8). In the PG and PG + MO were formed experimental periodontitis model. Compared to the PG, the decrease in the interleukin-6 (IL-6) and YKL-40 values in the PG + MO (p < 0.05, p < 0.05) was found to be significant in terms of statistical evaluation. As a result, MO decreased YKL-40 levels in the experimental periodontitis model. Although further research is needed, drugs containing MO can be used in the treatment of periodontal diseases.en_US
dc.identifier.doi10.1515/chem-2022-0310
dc.identifier.issn2391-5420
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85152567061en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1515/chem-2022-0310
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14853
dc.identifier.volume21en_US
dc.identifier.wosWOS:000964388000001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherDe Gruyter Poland Sp Z O Oen_US
dc.relation.ispartofOpen Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectExperimental Periodontitisen_US
dc.subjectYkl-40en_US
dc.subjectMoringa Oleiferaen_US
dc.subjectChitinase 3-Like Protein 1en_US
dc.subjectMoringa Treeen_US
dc.titleEffect of Moringa oleifera on serum YKL-40 level: In vivo rat periodontitis modelen_US
dc.typeArticleen_US

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