The Predictive Value of Periostin to Diagnose Crohn's Disease

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dc.contributor.authorKeskin, Muharrem
dc.contributor.authorTopkac, Ali
dc.date.accessioned2024-02-23T14:41:17Z
dc.date.available2024-02-23T14:41:17Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractBackground: There is still no sensitive and specific biomarker that can be used in the diagnosis and follow-up of Crohn's disease, so we aimed to assess the diagnostic accuracy of serum periostin levels in Crohn's disease. Methods: The study included 40 Crohn's disease patients aged 18-70 years and considered in remission (Crohn's Disease Activity Index < 150) at admission. Forty healthy volunteers were included in the study as the control group. Crohn's patients were divided into 3 main groups as <4 years, 4-8 years, and >8 years according to the follow-up period (in the group <4 years, it was subdivided into <2 and 2-4 years). Serum periostin levels were studied by enzyme-linked immunosorbent assay. Results: Forty Crohn's disease patients and 40 control participants were included in the study. In the Crohn's disease group, serum periostin level was 36.55 ng/mL, while it was 21 ng/ml. in the control group, P < .001. Periostin levels in the Crohn's disease group were higher in the groups with disease duration <4 years, 4-8 years, and >8 years compared to the control group (P < .001, P < .001, P = .038, respectively). For the diagnosis of Crohn's disease independent of disease duration, the cut-off periostin level was determined as 27.8 ng/mL, while the sensitivity and specificity for this value were 72.5% and 77.5%, respectively. Conclusion: Serum periostin levels of the patients followed up with the diagnosis of Crohn's disease in remission were found to be significantly higher than the healthy individuals, and cut-off values of serum periostin were obtained to both diagnose Crohn's disease and predict the course of the disease.en_US
dc.identifier.doi10.5152/tjg.2022.21875
dc.identifier.endpage135en_US
dc.identifier.issn2148-5607
dc.identifier.issue2en_US
dc.identifier.pmid35238781en_US
dc.identifier.scopus2-s2.0-85125683136en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage127en_US
dc.identifier.urihttps://doi.org/10.5152/tjg.2022.21875
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16779
dc.identifier.volume33en_US
dc.identifier.wosWOS:000765079600019en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal Of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPeriostinen_US
dc.subjectCrohn's Diseaseen_US
dc.subjectSerum Biomarkersen_US
dc.subjectCrohn's Disease Diagnosisen_US
dc.subjectInflammatory Bowel Diseaseen_US
dc.titleThe Predictive Value of Periostin to Diagnose Crohn's Diseaseen_US
dc.typeArticleen_US

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