Vitamin D Receptor Gene Polymorphisms in Childhood Brucellosis in Turkish Children

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dc.contributor.authorKaman, Ayse
dc.contributor.authorOz, Fatma Nur
dc.contributor.authorSahin, Gulseren
dc.contributor.authorMetin Akcan, Ozge
dc.date.accessioned2024-02-23T14:16:59Z
dc.date.available2024-02-23T14:16:59Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractObjective The vitamin D receptor gene (VDR) polymorphisms and the risk of various infections have been studied. An association with brucellosis and vitamin D levels has been investigated but not yet with VDR gene polymorphisms. We aimed to examine the association between VDR gene polymorphisms and susceptibility to childhood brucellosis. Methods This case-control study included patients with brucellosis and healthy controls. After extracting genomic DNA using a Qiagen blood DNA isolation kit, five VDR single nucleotide polymorphisms (SNPs), including Cdx-2, FokI, BsmI, ApaI, and TaqI gene, were amplified. Genetic distribution of these SNPs of VDR gene in patient and control groups were compared. Results A total of 38 patients with brucellosis and 89 healthy controls were evaluated. The genotype distribution of Cdx2, FokI, BsmI, and ApaI polymorphisms were similar between patients and healthy controls. However, the CC homozygous genotype for VDR gene TaqI was significantly overexpressed in patients compared with controls (23.7 vs. 7.9%; p = 0.042). The frequency of the C allele of the TaqI genotype was significantly different between patients and controls ((p = 0.018). On the other hand, presence of the A allele in the BsmI was associated considerably with an increased risk of brucellosis (p = 0.037). VDR polymorphism distribution was similar according to age, presence of complicated disease, and presence of bacteremia. The heterozygote TaqI polymorphism was more common in patients presented as subacute and chronic symptoms (p = 0.036). Conclusion Our results indicated the possible role in TaqI polymorphism of the VDR gene for the risk of brucellosis at the time of exposure to infection.en_US
dc.identifier.doi10.1055/s-0041-1732471
dc.identifier.endpage268en_US
dc.identifier.issn1305-7707
dc.identifier.issn1305-7693
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85111447252en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage262en_US
dc.identifier.urihttps://doi.org/10.1055/s-0041-1732471
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12876
dc.identifier.volume16en_US
dc.identifier.wosWOS:000675590800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofJournal Of Pediatric Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrucellosisen_US
dc.subjectChildrenen_US
dc.subjectVitamin D Receptor Gene Polymorphismen_US
dc.titleVitamin D Receptor Gene Polymorphisms in Childhood Brucellosis in Turkish Childrenen_US
dc.typeArticleen_US

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