Clinicopathologic and Surgical Characteristics Study of 151 Cases of GIST

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dc.contributor.authorSenturk, Mustafa
dc.contributor.authorYildirim, Mehmet Aykut
dc.contributor.authorCakir, Murat
dc.contributor.authorKisi, Omer
dc.date.accessioned2024-02-23T13:59:45Z
dc.date.available2024-02-23T13:59:45Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractBackground Gastrointestinal stromal tumor (GIST) is the most appearing mesenchymal tumor of the gastrointestinal system. In this study, we are aiming to share the most up to date knowledge about diagnosis and treatment of these tumors by transferring our clinical experience about GISTs. Methods The 151 patients who were operated between 2006-2020 and whose pathological examination was reported as GIST were analyzed retrospectively. Demographic, clinical, and pathological features and treatment methods of patients were evaluated. Results Seeventy-six of the patients were women and 75 of them were men whose age averages were 66.1 (31-86). The most common location was the stomach (55.6%), followed by the small intestine, retroperitoneal, large intestine, rectum, esophagus, and another organ. With surgical intervention, 139 of them had been cured. Twelve of cases were accepted as inoperable. The diameter of tumors in our cases were between 0.4 cm and 35 cm. Determined mitotic activity was <= 5 in 71 patients and 5 < in 80 patients. In 8 of 12 unresectable cases, it has been seen that partial remission after the treatment of 12-month tyrosine kinase inhibitors, C-KIT, was positive in 96.7% of our cases. CD34 and Ki-67 was analyzed in patients. CD34 was found positive in 98 (64.9%) of them, Ki-67 was positive in 82 (54.3%) patients. Patients had been observed for 40 months. Conclusion Despite GISTs are not appearing frequently, nowadays they have started to be seen more frequently than before with the growing present-day diagnostic methods. The ideal treatment is performing radical resection without leaving any tumor cells behind. Tyrosine kinase inhibitors have an important place in unresectable cases.en_US
dc.identifier.doi10.1007/s12029-020-00414-y
dc.identifier.endpage546en_US
dc.identifier.issn1941-6628
dc.identifier.issn1941-6636
dc.identifier.issue2en_US
dc.identifier.pmid32445057en_US
dc.identifier.scopus2-s2.0-85085388977en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage542en_US
dc.identifier.urihttps://doi.org/10.1007/s12029-020-00414-y
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11310
dc.identifier.volume52en_US
dc.identifier.wosWOS:000534847100001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Gastrointestinal Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGisten_US
dc.subjectImmunohistochemicalen_US
dc.subjectSurgical Treatmenten_US
dc.titleClinicopathologic and Surgical Characteristics Study of 151 Cases of GISTen_US
dc.typeArticleen_US

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