The relationship between glomerular filtration rate, and metabolic and inflammatory parameters in obese and non-obese patients with polycystic ovary syndrome

Basit Öğe Kaydı
dc.contributor.authorCan, Mustafa
dc.contributor.authorDuran, Cevdet
dc.contributor.authorGuney, Ibrahim
dc.contributor.authorElmas, Halis
dc.contributor.authorAyhan, Mehmet
dc.contributor.authorErdem, Said Sami
dc.date.accessioned2024-02-23T14:02:09Z
dc.date.available2024-02-23T14:02:09Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractAim: To investigate the relationship between glomerular filtration rates (GFR), and homeostasis model assesment of insulin resistance (HOMA-IR), C-reactive protein (CRP) and neutrophil to lymphocyte ratio (NLR) in patients with polycystic ovary syndrome (PCOS). Material and methods: Thirty-one overweight and obese PCOS patients with body mass index (BMI) >= 25 kg/m(2) and 25 non-obese PCOS patients with BMI < 25 kg/m(2) were included into patients' group, while 23 overweight and obese, and 25 non-obese age-and BMI-matched healthy individuals (aged between 18 and 40 years), were enrolled as controls. Levels of serum creatinine, glucose, insulin, CRP, and complete blood count were measured. eGFR, HOMA-IR and NLR were also calculated. Results: In PCOS group, HOMA-IR (p=0.001), CRP (p=0.025) and waist hip ratio (WHR) (p=0.011) were higher than controls. In obese PCOS sub-group, HOMA-IR (p=0.004) and WHR (p=0.002) were higher than obese controls. In non-obese PCOS sub-group, HOMA-IR (p=0.001) were higher than non-obese controls. In obese PCOS sub-group; HOMA-IR (p = 0.001) and CRP (p=0.001) levels were significantly higher than non-obese PCOS sub-group. In terms of other parameters, no significant difference was found between the groups. The analysis showed a negative correlation between GFR, and BMI and HOMA-IR in PCOS group, between GFR, WHR and insulin levels in obese PCOS sub-group, and between BMI, and HOMA-IR and NLR in non-obese PCOS sub-group. Conclusion: Although HOMA-IR and CRP were higher in PCOS group, there was no difference in NLR and GFR levels between those with PCOS and controls. (C) 2020 Sociedad Espanola de Arteriosclerosis. Published by Elsevier Espana, S.L.U. All rights reserved.en_US
dc.description.sponsorshipKonya Training and Research Hospitalen_US
dc.description.sponsorshipThe study was supported by the research fund of Konya Training and Research Hospital.en_US
dc.identifier.doi10.1016/j.arteri.2020.04.003
dc.identifier.endpage262en_US
dc.identifier.issn0214-9168
dc.identifier.issn1578-1879
dc.identifier.issue6en_US
dc.identifier.pmid32773256en_US
dc.identifier.scopus2-s2.0-85089134497en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage256en_US
dc.identifier.urihttps://doi.org/10.1016/j.arteri.2020.04.003
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11607
dc.identifier.volume32en_US
dc.identifier.wosWOS:000592017200003en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofClinica E Investigacion En Arteriosclerosisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGlomerular Filtration Rateen_US
dc.subjectInflammationen_US
dc.subjectNeutrophil To Lymphocyte Ratioen_US
dc.subjectObesityen_US
dc.subjectPotycystic Ovary Syndromeen_US
dc.titleThe relationship between glomerular filtration rate, and metabolic and inflammatory parameters in obese and non-obese patients with polycystic ovary syndromeen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu