Prevalence of H-pylori in gastric biopsy specimen in the southeastern region of Turkey

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dc.contributor.authorBilman, Fulya Bayindir
dc.contributor.authorOzdemir, Mehmet
dc.contributor.authorBaysal, Birol
dc.contributor.authorKurtoglu, Muhammed Guzel
dc.date.accessioned2024-02-23T14:35:26Z
dc.date.available2024-02-23T14:35:26Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractIntroduction: Helicobacter pylori is a Gramnegative, microaerophilic bacterium that colonizes human gastric mucosa. Gastric ulcer, duodenal ulcer, chronic atrophic gastritis, mucosa associated lymphoid tissue lymphoma, and stomach adenocarcinoma are associated with H. pylori as the etiological agent. Cytotoxin associated gene A (cagA), which is one of the most important virulence factors of H. pylori, encodes a 120145 kDa protein. The prevalence of cagA genes shows differences in H. pylori infections based on geographical area, and cagA positive H. pylori strains play an important role in pathogenesis of gastric carcinoma. Methodology: The aim of this study was to detect the prevalence of cagA and vacA genes in H. pylori isolates in adult patient groups in the southeastern region of Turkey. The presence of H. pylori was investigated in gastric biopsy specimens using the culture method, and polymerase chain reaction (PCR) analysis was performed to detect the presence of the cagA and vacA s1 genes. Results: H. pylori was detected in 65% (84/129) of patients who had gastrointestinal complaints. The number of vacA s1 and cagA genes of isolates were 44 (74.5%) and 31 (52.5%), respectively. Conclusions: H. pylori infection in southeastern region of Turkey with are comparable to those in developed countries. Patients with cagA and vacA positive H. pylori have a higher risk of severe inflammation and atrophy and should therefore be monitored for the development of gastric cancer.en_US
dc.identifier.doi10.3855/jidc.6690
dc.identifier.endpage1182en_US
dc.identifier.issn1972-2680
dc.identifier.issue11en_US
dc.identifier.pmid27886029en_US
dc.identifier.scopus2-s2.0-84997770201en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1177en_US
dc.identifier.urihttps://doi.org/10.3855/jidc.6690
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16026
dc.identifier.volume10en_US
dc.identifier.wosWOS:000394021500003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJ Infection Developing Countriesen_US
dc.relation.ispartofJournal Of Infection In Developing Countriesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHelicobacter Pylorien_US
dc.subjectCagaen_US
dc.subjectVaca S1en_US
dc.subjectPolymerase Chain Reactionen_US
dc.titlePrevalence of H-pylori in gastric biopsy specimen in the southeastern region of Turkeyen_US
dc.typeArticleen_US

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