Identifying Clinical Characteristics of Hypoparathyroidism in Turkey: HIPOPARATURK-NET Study

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dc.contributor.authorDegertekin, Ceyla Konca
dc.contributor.authorYavuz, Dilek Gogas
dc.contributor.authorPekkolay, Zafer
dc.contributor.authorSaygili, Emre
dc.contributor.authorUgur, Kader
dc.contributor.authorKoca, Arzu Or
dc.contributor.authorUnubol, Mustafa
dc.date.accessioned2024-02-23T13:43:32Z
dc.date.available2024-02-23T13:43:32Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractHypoparathyroidism is an orphan disease with ill-defined epidemiology that is subject to geographic variability. We conducted this study to assess the demographics, etiologic distribution, treatment patterns and complication frequency of patients with chronic hypoparathyroidism in Turkey. This is a retrospective, cross-sectional database study, with collaboration of 30 endocrinology centers located in 20 cities across seven geographical regions of Turkey. A total of 830 adults (mean age 49.6 +/- 13.5 years; female 81.2%) with hypoparathyroidism (mean duration 9.7 +/- 9.0 years) were included in the final analysis. Hypoparathyroidism was predominantly surgery-induced (n = 686, 82.6%). The insulting surgeries was carried out mostly due to benign causes in postsurgical group (SG) (n = 504, 73.5%) while patients in nonsurgical group (NSG) was most frequently classified as idiopathic (n = 103, 71.5%). The treatment was highly dependent on calcium salts (n = 771, 92.9%), calcitriol (n = 786, 94.7%) and to a lower extent cholecalciferol use (n = 635, 76.5%) while the rate of parathyroid hormone (n = 2, 0.2%) use was low. Serum calcium levels were most frequently kept in the normal range (sCa 8.5-10.5 mg/dL, n = 383, 46.1%) which might be higher than desired for this patient group. NSG had a lower mean plasma PTH concentration (6.42 +/- 5.53 vs. 9.09 +/- 7.08 ng/l, p < 0.0001), higher daily intake of elementary calcium (2038 +/- 1214 vs. 1846 +/- 1355 mg/day, p = 0.0193) and calcitriol (0.78 +/- 0.39 vs. 0.69 +/- 0.38 mcg/day, p = 0.0057), a higher rate of chronic renal disease (9.7% vs. 3.6%, p = 0.0017), epilepsy (6.3% vs. 1.6%, p = 0.0009), intracranial calcifications (11.8% vs. 7.3%, p < 0.0001) and cataracts (22.2% vs. 13.7%, p = 0.0096) compared to SG. In conclusion, postsurgical hypoparathyroidism is the dominant etiology of hypoparathyroidism in Turkey while the nonsurgical patients have a higher disease burden with greater need for medications and increased risk of complications than the postsurgical patients.en_US
dc.identifier.doi10.1007/s00223-021-00908-2
dc.identifier.endpage214en_US
dc.identifier.issn0171-967X
dc.identifier.issn1432-0827
dc.identifier.issue2en_US
dc.identifier.pmid34495356en_US
dc.identifier.scopus2-s2.0-85114447165en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage204en_US
dc.identifier.urihttps://doi.org/10.1007/s00223-021-00908-2
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10848
dc.identifier.volume110en_US
dc.identifier.wosWOS:000695738900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofCalcified Tissue Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHypoparathyroidismen_US
dc.subjectHypocalcemiaen_US
dc.subjectEpidemiologyen_US
dc.subjectTurkeyen_US
dc.subjectParathyroid Hormoneen_US
dc.titleIdentifying Clinical Characteristics of Hypoparathyroidism in Turkey: HIPOPARATURK-NET Studyen_US
dc.typeArticleen_US

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