Leptin Prevents U46619- and Angiotensin II-Elicited Contraction in Isolated Human Umbilical Vessels
dc.contributor.author | Duman, Ipek | |
dc.contributor.author | Soner, Burak Cem | |
dc.contributor.author | Irian, Salim Yalcin | |
dc.contributor.author | Sahin, Ayse Saide | |
dc.date.accessioned | 2024-02-23T14:29:38Z | |
dc.date.available | 2024-02-23T14:29:38Z | |
dc.date.issued | 2022 | |
dc.department | NEÜ | en_US |
dc.description.abstract | Objective: This study investigated the vasoactive responses of quiescent and pre-contracted isolated human umbilical veins and arteries to cumulative leptin. Materials and Methods: The vasoactive response of umbilical vessels pre-contracted with U46619 (10(-10)M) and angiotensin II (10(-6)M) to cumulative leptin (10(-11)-10(-7)M) were recorded in vitro. Results: Leptin did not affect the artery or vein basal tonus (p=1). The leptin-elicited relaxation in U46619-contracted vessels was greater in veins than in arteries (p<0.001). Incubation with N (omega)-nitro-L-arginine methyl ester (L-NAME) (10(-4)M) prevented the leptin-induced relaxation of the U46619 contraction response in the artery. The E-max and pD(2) values of the L-NAME-incubated veins were lower than those of the non-incubated veins (p<0.001 and p=0.001, respectively). The relaxation in angiotensin II-contracted veins was greater than that of the arteries (p<0.001). Incubation with L-NAME prevented leptin-induced relaxation in angiotensin II-contracted arteries. The E-max of leptin-induced relaxation of L-NAME-incubated veins was significantly lower than that of non-incubated veins (p=0.027); the pD(2) was similar. Conclusion: Leptin did not alter the resting tension of isolated umbilical vessels; however, the results indicated that leptin caused concentration-dependent relaxation in umbilical vessels pre-contracted with U46619 or angiotensin II. The maximum relaxation was greater in veins compared with arteries. Incubation with L-NAME completely inhibited leptin-induced relaxation in arteries and resulted in a significant inhibition in veins. | en_US |
dc.description.sponsorship | Necmettin Erbakan University [161218024] | en_US |
dc.description.sponsorship | Necmettin Erbakan University, Scientific Research Project Coordinator, funded the study. Grant number: 161218024. | en_US |
dc.identifier.doi | 10.14744/etd.2021.64249 | |
dc.identifier.endpage | 329 | en_US |
dc.identifier.issn | 2149-2247 | |
dc.identifier.issn | 2149-2549 | |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 324 | en_US |
dc.identifier.uri | https://doi.org/10.14744/etd.2021.64249 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12452/14785 | |
dc.identifier.volume | 44 | en_US |
dc.identifier.wos | WOS:000859778900014 | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.language.iso | en | en_US |
dc.publisher | Erciyes Univ Sch Medicine | en_US |
dc.relation.ispartof | Erciyes Medical Journal | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Angiotensin Ii | en_US |
dc.subject | Leptin | en_US |
dc.subject | U46619 | en_US |
dc.subject | Umbilical Artery | en_US |
dc.subject | Umbilical Vein | en_US |
dc.title | Leptin Prevents U46619- and Angiotensin II-Elicited Contraction in Isolated Human Umbilical Vessels | en_US |
dc.type | Article | en_US |