Associations of IL-4, IL-4R, IL-17A, and IL-17F Polymorphisms with Colorectal Cancer Risk: A Meta-Analysis, Meta-Regression, and Trial Sequential Analysis

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dc.contributor.authorJavadirad, Etrat
dc.contributor.authorSadeghi, Masoud
dc.contributor.authorOltulu, Pembe
dc.contributor.authorSadafi, Sepehr
dc.date.accessioned2024-02-23T14:20:58Z
dc.date.available2024-02-23T14:20:58Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractBoth interleukin (IL)-4 and IL-17 polymorphisms may be involved in the pathogenesis and progression of colorectal cancer (CRC). Herein, we designed a meta-analysis to assess the associations between IL-4, IL-4R, IL-17A, and IL-17F polymorphisms and CRC risk. Scopus, Web of Science, Cochrane Library, and PubMed databases were searched to retrieve articles published until October 21, 2021. We used crude odds ratio (OR) and 95% confidence interval assessing the association of the polymorphisms and CRC risk in 5 genetic models. Trial sequential analysis for the primary analyses was used to control random errors. Twenty-three studies (8: IL-4 rs2243250, 4: IL-4R rs1801275, 5: IL-17A rs2275913, and 6: IL-17F rs763780) were involved in the meta-analysis. The pooled OR (P-value) for the association between IL-4 rs2243250 polymorphism and the CRC risk was 1.11 (0.08), 1.27 (0.12), 1.07 (0.37), 1.09 (0.17), and 1.22 (0.12), for IL-4R rs1801275 polymorphism was 0.71 (0.18), 1.05 (0.76), 0.86 (0.37), 0.87 (0.41), and 0.69 (0.39), for IL-17A rs2275913 polymorphism was 1.83 (0.0003), 1.73 (0.06), 1.47 (<0.001), 1.61 (0.001), and 1.42 (0.15), and for IL-17F rs763780 polymorphism was 1.07 (0.48), 5.33 (0.02), 1.08 (0.49), 1.08 (0.47), and 8.42 (0.002) in allelic, homozygous, heterozygous, recessive, and dominant models, respectively. The G allele and GA genotype of IL-17A rs2275913 polymorphism and the CC genotype of IL-17F rs763780 polymorphism had an elevated risk in CRC cases. The ethnicity and genotyping method, sample size, control, and publication year were effective factors on the pooled results.en_US
dc.identifier.doi10.1089/jir.2021.0204
dc.identifier.endpage219en_US
dc.identifier.issn1079-9907
dc.identifier.issn1557-7465
dc.identifier.issue5en_US
dc.identifier.pmid35576490en_US
dc.identifier.scopus2-s2.0-85130138710en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage203en_US
dc.identifier.urihttps://doi.org/10.1089/jir.2021.0204
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13382
dc.identifier.volume42en_US
dc.identifier.wosWOS:000833036000003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofJournal Of Interferon And Cytokine Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectColorectal Neoplasmsen_US
dc.subjectPolymorphismen_US
dc.subjectInterleukin-4en_US
dc.subjectInterleukin-17en_US
dc.subjectMeta-Analysisen_US
dc.titleAssociations of IL-4, IL-4R, IL-17A, and IL-17F Polymorphisms with Colorectal Cancer Risk: A Meta-Analysis, Meta-Regression, and Trial Sequential Analysisen_US
dc.typeArticleen_US

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