Zonulin and claudin-5 levels in multisystem inflammatory syndrome and SARS-CoV-2 infection in children

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dc.contributor.authorKilic, Ahmet O.
dc.contributor.authorAkin, Fatih
dc.contributor.authorYazar, Abdullah
dc.contributor.authorAkcan, Ozge Metin
dc.contributor.authorTopcu, Cemile
dc.contributor.authorAydin, Orkun
dc.date.accessioned2024-02-23T14:24:31Z
dc.date.available2024-02-23T14:24:31Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractAim SARS-CoV-2 infection in children is generally asymptomatic or mild; however, it can lead to a life-threatening clinical condition, multisystem inflammatory syndrome in children (MIS-C), days or weeks after the infection. Increased intestinal permeability isa possible triggering factor at the onset of the hyperinflammation associated with MIS-C. Zonulin and claudin-5 are involved in intestinal permeability. In this study, we aimed to investigate serum zonulin and claudin-5 levels in SARS-CoV-2 infection and MIS-C disease. Methods The study group consisted of children diagnosed with MIS-C or SARS-CoV-2 infection who presented to a university hospital paediatric emergency or infectious diseases departments. The control group included well patients seen at the General Pediatrics units for routine follow-up. Serum zonulin and claudin-5 levels were measured at the time of diagnosis. Results Fifteen patients were included in the MIS-C group, 19 in the SARS-CoV-2 infection group and 21 in the control group. The mean zonulin level in the MIS-C group was significantly higher than in the control group (P < 0.001). Mean Claudin-5 levels were Psignificantly lower in the SARS-CoV-2 infection group than in the control group (P < 0.001). Conclusion These results indicate that increased intestinal permeability may be involved in the pathogenesis of SARS-CoV-2 infection and MIS-C disease. Larger clinical trials are needed to clarify the role of serum zonulin and claudin-5 on intestinal permeability in MIS-C and SARS-CoV-2 infection in children.en_US
dc.identifier.doi10.1111/jpc.16033
dc.identifier.endpage1565en_US
dc.identifier.issn1034-4810
dc.identifier.issn1440-1754
dc.identifier.issue9en_US
dc.identifier.pmid35638118en_US
dc.identifier.scopus2-s2.0-85130893430en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1561en_US
dc.identifier.urihttps://doi.org/10.1111/jpc.16033
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13987
dc.identifier.volume58en_US
dc.identifier.wosWOS:000802800400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Paediatrics And Child Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChildrenen_US
dc.subjectClaudin-5en_US
dc.subjectMultisystem Inflammatory Syndrome (Mis-C)en_US
dc.subjectSars-Cov-2 Infectionen_US
dc.subjectZonulinen_US
dc.titleZonulin and claudin-5 levels in multisystem inflammatory syndrome and SARS-CoV-2 infection in childrenen_US
dc.typeArticleen_US

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