The effect of different application timings of hyperbaric oxygen treatment on nerve regeneration in rats

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dc.contributor.authorInce, Bilsev
dc.contributor.authorArslan, Abdullah
dc.contributor.authorDadaci, Mehmet
dc.contributor.authorOltulu, Pembe
dc.contributor.authorBilgen, Fatma
dc.date.accessioned2024-02-23T12:53:02Z
dc.date.available2024-02-23T12:53:02Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractBackgroundThe aim of the study was to determine the effect of different application timings of hyperbaric oxygen treatment (HBO) on nerve regeneration in rats. Materials and MethodsA total of forty 12-week-old female Wistar albino rats were used. The sciatic nerve was transected. The nerve ends were then realigned and repaired using standard microsurgical techniques. Animals were randomly assigned to four groups: 1) No hyperbaric oxygen, sectioned and repaired; 2) HBO started at postoperative first hour, sectioned and repaired; 3) HBO started at postoperative first week, sectioned, and repaired; and 4) HBO started at postoperative second week, sectioned, and repaired. All rats in all groups were evaluated with gait analysis at 8 and 16 weeks postoperatively. Sciatic function index was calculated. Sciatic nerve samples were taken after gait analysis at 16th week. Foreign body reaction, the intensity of the inflammatory cells and types, repair-associated vascular proliferation in the field, axonal vacuolar degeneration of the fibers from the cut line transition density and switching layout, and myelinization density with perineural sheath were evaluated histopathologically. ResultsAt the 16th week, group 2 demonstrated the best gait analysis results. Gait analysis was better for group 3 than groups 1 and 4 (P<0.05). No significant differences were observed among the groups in inflammation (P>0.05). Fibrosis was statistically less in group 2 than that in other groups (P<0.05); however, no significant differences were observed among groups 1, 3, and 4 (P>0.05). ConclusionsOur results suggest that initiating HBO early after nerve repair will make a positive impact on recovery. (c) 2016 Wiley Periodicals, Inc. Microsurgery 36:586-592, 2016.en_US
dc.description.sponsorshipNecmettin Erbakan University, Department of scientific research projects [131218025]en_US
dc.description.sponsorshipThe authors thank Mehmet Uyar, MD, for his statistical analysis support. Bilsev Ince, MD is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. The research was not sponsored by an outside organization. All of the authors have agreed to allow full access to the primary data and to allow the journal to review the data if requested. None of the authors has a financial interest in any of the products, devices, or drugs mentioned in this manuscript. This research was supported by Necmettin Erbakan University, Department of scientific research projects (No: 131218025).en_US
dc.identifier.doi10.1002/micr.30023
dc.identifier.endpage592en_US
dc.identifier.issn0738-1085
dc.identifier.issn1098-2752
dc.identifier.issue7en_US
dc.identifier.pmid26773276en_US
dc.identifier.scopus2-s2.0-84955166346en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage586en_US
dc.identifier.urihttps://doi.org/10.1002/micr.30023
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10608
dc.identifier.volume36en_US
dc.identifier.wosWOS:000387217200009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofMicrosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleThe effect of different application timings of hyperbaric oxygen treatment on nerve regeneration in ratsen_US
dc.typeArticleen_US

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