Successful use of fondaparinux in a child with heparin-induced thrombocytopenia

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dc.contributor.authorTokgoz, Huseyin
dc.contributor.authorCaliskan, Umran
dc.contributor.authorDemir, Muzaffer
dc.date.accessioned2024-02-23T14:21:12Z
dc.date.available2024-02-23T14:21:12Z
dc.date.issued2012
dc.departmentNEÜen_US
dc.description.abstractHeparin-induced thrombocytopenia (HIT) is a well described side effect of heparin therapy. A 12-year-old boy developed deep-vein thrombosis. Risk factors for initial thrombosis are antiphospholipid syndrome and heterozygous mutation for prothrombin G20210A. Anticoagulant therapy with warfarin for 12 months was effective, but discontinuation of warfarin after 12 months resulted in recurrence of thrombosis. Unfractionated heparin (UFH) was initiated during the acute period, but heparin-induced thrombocytopenia developed. Transition from UFH to fondaparinux resulted in successful anticoagulation for a period of platelet recovery. We report a case of HIT developing with a background of prothrombotic genetic risk factors and antiphospholipid syndrome. This case study highlights several difficulties in pediatric HIT cases. Blood Coagul Fibrinolysis 23: 769-771 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.en_US
dc.identifier.doi10.1097/MBC.0b013e328358afc9
dc.identifier.endpage771en_US
dc.identifier.issn0957-5235
dc.identifier.issn1473-5733
dc.identifier.issue8en_US
dc.identifier.pmid22964766en_US
dc.identifier.scopus2-s2.0-84870242925en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage769en_US
dc.identifier.urihttps://doi.org/10.1097/MBC.0b013e328358afc9
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13495
dc.identifier.volume23en_US
dc.identifier.wosWOS:000310837200016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofBlood Coagulation & Fibrinolysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntiphospholipid Syndromeen_US
dc.subjectFondaparinuxen_US
dc.subjectHeparin-Induced Thrombocytopeniaen_US
dc.titleSuccessful use of fondaparinux in a child with heparin-induced thrombocytopeniaen_US
dc.typeArticleen_US

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